The Scourge of Antibiotic Resistance: The Important Role of the Environment

被引：446

作者：

Finley, Rita L. ^{[1
]}

Collignon, Peter ^{[2
,3
,4
]}

Larsson, D. G. Joakim ^{[5
]}

McEwen, Scott A. ^{[6
]}

Li, Xian-Zhi ^{[7
]}

Gaze, William H. ^{[8
]}

Reid-Smith, Richard ^{[9
]}

Timinouni, Mohammed ^{[10
]}

Graham, David W. ^{[11
]}

Topp, Edward ^{[12
]}

机构：

[1] Publ Hlth Agcy Canada, Ctr Food Borne Environm & Zoonot Infect Dis, Guelph, ON N1H 8J1, Canada

[2] Australian Natl Univ, Canberra Hosp, Infect Dis Unit, Canberra, ACT 0200, Australia

[3] Australian Natl Univ, Canberra Hosp, Dept Microbiol, Canberra, ACT 0200, Australia

[4] Australian Natl Univ, Canberra Clin Sch, Canberra, ACT 0200, Australia

[5] Gothenburg Univ, Dept Infect Dis, Inst Biomed, S-41124 Gothenburg, Sweden

[6] Univ Guelph, Ontario Vet Coll, Dept Populat Med, Guelph, ON N1G 2W1, Canada

[7] Hlth Canada, Vet Drugs Directorate, Ottawa, ON K1A 0L2, Canada

[8] Univ Exeter, Sch Med, Knowledge Spa, European Ctr Environm & Human Hlth,Royal Cornwall, Truro, England

[9] Publ Hlth Agcy Canada, Lab Foodborne Zoonoses, Guelph, ON N1H 8J1, Canada

[10] Pasteur Inst Morocco, Mol Bacteriol Lab, Casablanca, Morocco

[11] Newcastle Univ, Sch Civil Engn & Geosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[12] Agr & Agri Food Canada, London, ON, Canada

来源：

CLINICAL INFECTIOUS DISEASES | 2013年 / 57卷 / 05期

基金：

瑞典研究理事会;

关键词：

antibiotic resistance; environment; human resistant infections; ANIMAL FEEDING OPERATIONS; ANTIMICROBIAL RESISTANCE; ACINETOBACTER-BAUMANNII; ESCHERICHIA-COLI; BETA-LACTAMASES; WATER TREATMENT; AQUATIC ENVIRONMENT; DRINKING-WATER; PUBLIC-HEALTH; TYPHOID-FEVER;

D O I：

10.1093/cid/cit355

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibiotic resistance and associated genes are ubiquitous and ancient, with most genes that encode resistance in human pathogens having originated in bacteria from the natural environment (eg, beta-lactamases and fluoroquinolones resistance genes, such as qnr). The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome. This highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management. We need to take more steps to decrease the spread of resistance genes in environmental bacteria into human pathogens, to decrease the spread of resistant bacteria to people and animals via foodstuffs, wastes and water, and to minimize the levels of antibiotics and antibiotic-resistant bacteria introduced into the environment. Reducing this risk must include improved management of waste containing antibiotic residues and antibiotic-resistant microorganisms.

引用

页码：704 / 710

页数：7

共 72 条

[1] Antibiotics in Feed Induce Prophages in Swine Fecal Microbiomes [J].