Impact of Low- or High-Flux Haemodialysis and Online Haemodiafiltration on Inflammatory Markers and Lipid Profile in Chronic Haemodialysis Patients

被引：11
作者：
Akoglu, Hadim [1 ]
Dede, Fatih [1 ]
Piskinpasa, Serhan [1 ]
Falay, Mesude Y. [2 ]
Odabas, Ali Riza [1 ]
机构：
[1] Ankara Numune Training & Res Hosp, Dept Nephrol, Ankara, Turkey
[2] Ankara Numune Training & Res Hosp, Dept Hematol, Ankara, Turkey
来源：
BLOOD PURIFICATION | 2013年 / 35卷 / 04期
关键词：
Dialyser flux; Dyslipidaemia; Haemodialysis; Inflammation; Online haemodiafiltration; ULTRAPURE DIALYSATE; TNF-ALPHA; MEMBRANES; INTERLEUKIN-6; MORTALITY; DYSLIPIDEMIA; CROSSOVER; PROTEIN; TRIAL;
D O I：
10.1159/000348453
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background/Aims: We aimed to evaluate the impact of low-or high-flux haemodialysis (HD) and online haemodiafiltration (OL-HDF) on inflammation and the lipid profile in HD patients. Methods: 50 HD patients were assigned to two groups for HD with low-flux (n = 25) or high-flux (n = 25) polysulphone dialysers for 6 weeks. Subsequently, all patients were haemodialysed with a low-flux polysulphone dialyser for 6 weeks, then transferred to OL-HDF for another 6 weeks. Blood samples for lipids and inflammatory markers (IL-6, IL-8, TNF-alpha, hs-CRP) were obtained at baseline and every 6 weeks. Results: Changes in inflammatory markers and lipids from baseline to the 6-week dialysis period did not differ between low-and high-flux groups. When patients were transferred from low-flux HD to OL-HDF, IL-6, IL-8, and TNF-a levels significantly decreased whereas HDL and LDL cholesterol significantly increased. Conclusion: Low-and high-flux polysulphone membranes had similar effects on lipids and inflammatory markers, whereas OL-HDF potently reduced pro-inflammatory cytokines. Copyright (C) 2013 S. Karger AG, Basel
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收藏
页码：258 / 264
页数：7
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