Cytoskeletal Proteins: Shaping Progression of Hepatitis C Virus-Induced Liver Disease

被引：4

作者：

Ghosh, Sriparna ^{[1
,2
]}

Kaplan, Keith J. ^{[1
,2
]}

Schrum, Laura W. ^{[1
,2
]}

Bonkovsky, Herbert L. ^{[1
,2
,3
,4
]}

机构：

[1] Carolinas Med Ctr, Liver Biliary Pancreat Ctr, Charlotte, NC 28203 USA

[2] Univ N Carolina, Sch Med, Carolinas Med Ctr, Charlotte, NC 28223 USA

[3] Univ Connecticut, Ctr Hlth, Dept Med, Farmington, CT USA

[4] Univ Connecticut, Ctr Hlth, Dept Mol Microbial & Struct Biol, Farmington, CT USA

来源：

INTERNATIONAL REVIEW OF CELL AND MOLECULA BIOLOGY, VOL 302 | 2013年 / 302卷

关键词：

SINUSOIDAL ENDOTHELIAL FENESTRAE; PRIMARY BILIARY-CIRRHOSIS; B TYPE-I; HEPATOCELLULAR-CARCINOMA; CORE PROTEIN; INTERMEDIATE-FILAMENTS; DIFFERENTIAL EXPRESSION; ENDOPLASMIC-RETICULUM; CARBON-TETRACHLORIDE; ACTIN CYTOSKELETON;

D O I：

10.1016/B978-0-12-407699-0.00005-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatitis C virus (HCV) infection, which results in chronic hepatitis C (CHC) in most patients (70-85%), is a major cause of liver disease and remains a major therapeutic challenge. The mechanisms determining liver damage and the key factors that lead to a high rate of CHC remain imperfectly understood. The precise role of cytoskeletal (CS) proteins in HCV infection remains to be determined. Some studies including our recent study have demonstrated that changes occur in the expression of CS proteins in HCV-infected hepatocytes. A variety of host proteins interact with HCV proteins. Association between CS and HCV proteins may have implications in future design of CS protein-targeted therapy for the treatment for HCV infection. This chapter will focus on the interaction between host CS and viral proteins to signify the importance of this event in HCV entry, replication and transportation.

引用

页码：279 / 319

页数：41

共 177 条

[1] Hepatitis C virus and other Flaviviridae viruses enter cells via low density lipoprotein receptor [J].