Nanotechnology in interventional cardiology: A state-of-the-art review

被引：10

作者：

Almas, Talal ^{[4
]}

Haider, Rakhshan ^{[1
]}

Malik, Jahanzeb ^{[2
]}

Mehmood, Asim ^{[1
]}

Alvi, Areej ^{[1
]}

Naz, Hifza ^{[3
]}

Satti, Danish Iltaf ^{[1
]}

Zaidi, Syed Muhammad Jawad ^{[5
]}

AlSubai, Abdulla K. ^{[4
]}

AlNajdi, Sara ^{[4
]}

Alsufyani, Reema ^{[4
]}

Ramtohul, Rahul Krylov ^{[4
]}

Almesri, Abdullah ^{[4
]}

Alsufyani, Majid ^{[4
]}

Al-Bunnia, Abdulaziz H. ^{[4
]}

Alghamdi, Haitham Ahmed S. ^{[4
]}

Sattar, Yasar ^{[6
]}

Alraies, M. Chadi ^{[7
]}

Raina, Sameer ^{[6
]}

机构：

[1] Shifa Int Hosp, Dept Med, Islamabad, Pakistan

[2] Cardiovasc Analyt Grp, Hong Kong, Peoples R China

[3] Univ Milan, Sch Med & Surg, Bicocca, Italy

[4] Royal Coll Surgeons Ireland, Dublin, Ireland

[5] Rawalpindi Med Univ, Dept Med, Rawalpindi, Pakistan

[6] West Virginia Univ, Dept Cardiol, Morgantown, VA USA

[7] Wayne State Univ, Detroit Med Ctr, Dept Cardiol, Detroit, MI USA

来源：

IJC HEART & VASCULATURE | 2022年 / 43卷

关键词：

Invasive cardiology; Nanoparticles; Optical coherence tomography; Gold; Bacterial biofilm; IRON-OXIDE NANOPARTICLES; GOLD-NANOPARTICLES; SILVER NANOPARTICLES; LEADLESS; ATHEROSCLEROSIS; TOXICITY; NANOMATERIALS; COMPLICATIONS; INFLAMMATION; ANGIOGRAPHY;

D O I：

10.1016/j.ijcha.2022.101149

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Despite the contemporary techniques and devices available for invasive cardiology procedures, the current diagnostic, and interventional modalities have many shortcomings. As a contemporary cross-disciplinary tech-nique, nanotechnology has demonstrated great potential in interventional cardiology practice. It has a pivotal role in detecting sensitive cardiac biomarkers, nanoparticle-enhanced gadolinium (Gd) contrast to enhance the detection of atherosclerotic cardiovascular disease (ASCVD), and multimodal imaging like including optical coherence tomography (OCT)/infrared luminescence (IR) for coronary plaque characterization. Furthermore, in invasive cardiology, the potential benefit is in miniaturized cardiac implantable electronic devices (CIEDs), including leadless pacemakers and piezoelectric nanogenerators to self-power symbiotic cardiac devices. Nanoparticles are ideal for therapeutic drug delivery systems for atherosclerotic plaque regression, regeneration of fibrotic cardiomyocytes, and disruption of bacterial biofilm to enhance and prolong the effects of antimicrobial agents in infective endocarditis (IE). In summary, nanotechnology-assisted therapies can overtake conventional invasive cardiology and expand the horizon of microtechnology in the diagnosis and treatment of CAD in the foreseeable future.

引用

页数：14

共 124 条

[1] Toxicity of iron oxide nanoparticles: Size and coating effects [J].