Comparison of efficacy of Salmonella typhimurium A1-R and chemotherapy on stem-like and non-stem human pancreatic cancer cells

被引：73

作者：

Hiroshima, Yukihiko ^{[1
,2
,3
]}

Zhao, Ming ^{[1
]}

Zhang, Yong ^{[1
]}

Maawy, Ali ^{[2
]}

Hassanein, Mohamed K. ^{[1
]}

Uehara, Fuminari ^{[1
,2
]}

Miwa, Shinji ^{[1
,2
]}

Yano, Shuya ^{[1
,2
]}

Momiyama, Masashi ^{[3
]}

Suetsugu, Atsushi ^{[1
,2
,4
]}

Chishima, Takashi ^{[3
]}

Tanaka, Kuniya ^{[3
]}

Bouvet, Michael ^{[2
]}

Endo, Itaru ^{[3
]}

Hoffman, Robert M. ^{[1
,2
]}

机构：

[1] AntiCanc Inc, San Diego, CA USA

[2] Univ Calif San Diego, Dept Surg, San Diego, CA 92103 USA

[3] Yokohama City Univ, Grad Sch Med, Yokohama, Kanagawa 232, Japan

[4] Gifu Univ, Grad Sch Med, Gifu, Japan

来源：

CELL CYCLE | 2013年 / 12卷 / 17期

关键词：

METASTATIC MOUSE MODELS; TUMOR-TARGETING MUTANT; NUDE-MICE;

D O I：

10.4161/cc.25872

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The XPA1 human pancreatic cancer cell line is dimorphic, with spindle stem-like cells and round non-stem cells. We report here the in vitro IC50 values of stem-like and non-stem XPA1 human pancreatic cells cells for: (1) 5-fluorouracil (5-FU), (2) cisplatinum (CDDP), (3) gemcitabine (GEM), and (4) tumor-targeting Salmonella typhimurium A1-R (A1-R). IC50 values of stem-like XPA1 cells were significantly higher than those of non-stem XPA1 cells for 5-FU (P = 0.007) and CDDP (P = 0.012). In contrast, there was no difference between the efficacy of A1-R on stem-like and non-stem XPA1 cells. In vivo, 5-FU and A1-R significantly reduced the tumor weight of non-stem XPA1 cells (5-FU; P = 0.028; A1-R; P = 0.011). In contrast, only A1-R significantly reduced tumor weight of stem-like XPA1 cells (P = 0.012). The combination of A1-R with 5-FU improved the antitumor efficacy compared with 5-FU monotherapy on the stem-like cells (P = 0.004). The results of the present report indicate A1-R is a promising therapy for chemo-resistant pancreatic cancer stem-like cells. © 2013 Landes Bioscience.

引用

页码：2774 / 2780

页数：7

共 22 条

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