Dose variation and regimen modification of adjuvant chemotherapy in daily practice affect survival of stage I-II and operable stage III Taiwanese breast cancer patients

被引：13

作者：

Kuo, Sung-Hsin ^{[2
,3
,6
]}

Lien, Huang-Chun ^{[4
]}

You, San-Lin ^{[5
]}

Lu, Yen-Shen ^{[2
,3
]}

Lin, Ching-Hung ^{[2
,3
]}

Chen, T. -Zui ^{[5
]}

Huang, Chiun-Sheng ^{[1
]}

机构：

[1] Natl Taiwan Univ Hosp, Dept Surg, Taipei, Taiwan

[2] Natl Taiwan Univ, Coll Med, Canc Res Ctr, Taipei 10764, Taiwan

[3] Natl Taiwan Univ Hosp, Dept Oncol, Taipei, Taiwan

[4] Natl Taiwan Univ Hosp, Dept Pathol, Taipei, Taiwan

[5] Natl Taiwan Univ, Coll Publ Hlth, Grad Inst Epidemiol, Taipei, Taiwan

[6] Natl Taiwan Univ Hosp, Yun Lin Branch, Dept Oncol, Yunlin, Taiwan

来源：

BREAST | 2008年 / 17卷 / 06期

关键词：

Prognostic factor; Dose and regimen of adjuvant chemotherapy; Taiwanese; Breast cancer; Survival;

D O I：

10.1016/j.breast.2008.05.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To assess the effect of a non-standard dose and regimen of adjuvant chemotherapy on the clinical outcome in stage I-II and operable stage III Taiwanese breast cancer patients. Variables Studied included treatment variation (regimen and dose of adjuvant therapy), lymph node status, tumor size. histologic grade, and hormone receptor status. Cox's multivariate regression analyses were used to select prognostic factors significant for disease-free Survival (DFS) and overall survival (OS). In the multivariate analysis, lymph node-positive, a tumor size greater than 5 cm, grade III, hormone receptor-negative status, and non-standard adjuvant chemotherapy were independent prognostic factors for DFS and/or OS. Node-positive patients treated with standard adjuvant chemotherapy had a significantly better DFS (HR = 0.6; P = 0.032) and OS (HR = 0.54; P = 0.025) than those treated with non-standard adjuvant chemotherapy. Breast cancer patients receiving standard adjuvant chemotherapy have a better DFS and OS than those receiving non-standard adjuvant chemotherapy. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：646 / 653

页数：8

共 36 条

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