Discovery of Innovative Small Molecule Therapeutics

被引：19
作者：
Abou-Gharbia, Magid [1 ]
机构：
[1] Temple Univ, Ctr Drug Discovery Res, Sch Pharm, Philadelphia, PA 19140 USA
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 52卷 / 01期
关键词：
GENERATION DOPAMINERGIC AGENTS; EARLY DRUG DISCOVERY; ANTIPSYCHOTIC ACTIVITY; BIOLOGICAL EVALUATION; RECEPTOR ANTAGONIST; MASS-SPECTROMETRY; SEROTONIN; 5-HT1A; NATURAL-PRODUCTS; FK506; LECOZOTAN;
D O I：
10.1021/jm8012823
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：2 / 9
页数：8
相关论文
共 51 条
[1]  
ABOU-GHARBIA M, 1990, Drugs of the Future, V15, P1093
[2]  
ABOU-GHARBIA M, 1989, Drugs of the Future, V14, P442
[3]  
ABOU-GHARBIA M, 1991, Drugs of the Future, V16, P1008
[4]  
ABOU-GHARBIA M, 1988, Drugs of the Future, V13, P541
[5]   Synthesis and SAR of adatanserin:: Novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT1A and 5-HT2 activity as potential anxiolytic and antidepressant agents [J].
Abou-Gharbia, MA ;
Childers, WE ;
Fletcher, H ;
McGaughey, G ;
Patel, U ;
Webb, MB ;
Yardley, J ;
Andree, T ;
Boast, C ;
Kucharik, RJ ;
Marquis, K ;
Morris, H ;
Scerni, R ;
Moyer, JA .
JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (25) :5077-5094
[6]   POLYCYCLIC ARYLPIPERAZINYL AND HETEROARYLPIPERAZINYL IMIDES AS 5-HT1A RECEPTOR LIGANDS AND POTENTIAL ANXIOLYTIC AGENTS - SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP STUDIES [J].
ABOUGHARBIA, M ;
PATEL, UR ;
WEBB, MB ;
MOYER, JA ;
ANDREE, TH ;
MUTH, EA .
JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (07) :1382-1392
[7]   ANTIPSYCHOTIC ACTIVITY OF SUBSTITUTED GAMMA-CARBOLINES [J].
ABOUGHARBIA, M ;
PATEL, UR ;
WEBB, MB ;
MOYER, JA ;
ANDREE, TH ;
MUTH, EA .
JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (10) :1818-1823
[8]   PSYCHOTROPIC AGENTS - SYNTHESIS AND ANTIPSYCHOTIC ACTIVITY OF SUBSTITUTED BETA-CARBOLINES [J].
ABOUGHARBIA, M ;
PATEL, UR ;
MOYER, JA ;
MUTH, EA .
JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (06) :1100-1105
[9]   8-HYDROXY-2-(DI-NORMAL-PROPYLAMINO)TETRALIN, A NEW CENTRALLY ACTING 5-HYDROXYTRYPTAMINE RECEPTOR AGONIST [J].
ARVIDSSON, LE ;
HACKSELL, U ;
NILSSON, JLG ;
HJORTH, S ;
CARLSSON, A ;
LINDBERG, P ;
SANCHEZ, D ;
WIKSTROM, H .
JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (08) :921-923
[10]   Structural properties of matrix metalloproteinases [J].
Bode, W ;
Fernandez-Catalan, C ;
Tschesche, H ;
Grams, F ;
Nagase, H ;
Maskos, K .
CELLULAR AND MOLECULAR LIFE SCIENCES, 1999, 55 (04) :639-652
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