Changes in cognition and health-related quality of life with unilateral thalamotomy for Parkinsonian tremor

被引：12

作者：

Nijhawan, Sunita R. ^{[1
]}

Banks, Sarah J. L. ^{[1
]}

Aziz, Tipu Z. ^{[2
,3
]}

Panourias, Ioannis ^{[4
]}

Gregory, Ralph ^{[3
]}

Yianni, John ^{[3
]}

Parkin, Simon ^{[3
]}

Joint, Carole ^{[4
]}

Scott, Richard B. ^{[1
,3
]}

机构：

[1] Radcliffe Infirm, Russell Cairns Unit, Dept Clin Neuropsychol, Oxford OX2 6HE, England

[2] Radcliffe Infirm, Dept Neurol Surg, Oxford OX2 6HE, England

[3] Radcliffe Infirm, Oxford Movement Disorder Grp, Oxford OX2 6HE, England

[4] Univ Hosp Larissa, Dept Neurosurg, Thessalia, Greece

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2009年 / 16卷 / 01期

关键词：

Parkinson's disease; Tremor; Thalamotomy; Cognition; Health-related quality of life; OUTCOME FOLLOWING PALLIDOTOMY; SURGICAL-TREATMENT; LANGUAGE; THALAMUS; DISEASE; LESIONS;

D O I：

10.1016/j.jocn.2008.03.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cognitive functioning and health-related quality of life were assessed pre- and post-operatively in a consecutive series of 31 Parkinson's disease patients who underwent stereotactic unilateral thalamotomy (22 left-sided, 9 right-sided) for tremor alleviation. Neuropsychological functions assessed included verbal and visual memory, language and speech production, verbal and non-verbal reasoning. and attention and working memory. Health-related quality of life measures included both general and disease-specific questionnaires. We found a statistically significant post-operative decline in phonetic verbal fluency scores for left-operated patients, as well its improvements in self-ratings of stigma and bodily discomfort oil the disease-specific quality of life questionnaire. These findings Suggest that thalamotomy, when indicated, has limited cognitive sequelae and may result in improved quality of life in areas specific to Parkinson's disease. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：44 / 50

页数：7

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