Partial volumes of cholesterol and monounsaturated diacylphosphatidylcholines in mixed bilayers

被引：4

作者：

Gallova, J. ^{[1
]}

Klacsova, M. ^{[1
]}

Devinsky, F. ^{[1
]}

Balgavy, P. ^{[1
]}

机构：

[1] Comenius Univ, Fac Pharm, SK-83232 Bratislava, Slovakia

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 2015年 / 190卷

关键词：

Densitometry; Cholesterol; Isobaric thermal expansivity; Liquid-ordered phase; Molecular volume; Phosphatidylcholine; NUCLEAR-MAGNETIC-RESONANCE; PARTIAL MOLECULAR VOLUMES; LIPID-BILAYERS; UNSATURATED PHOSPHATIDYLCHOLINES; UNILAMELLAR VESICLES; COMPONENT VOLUMES; PHASE-DIAGRAMS; CELL-MEMBRANES; FLUID; DOPC;

D O I：

10.1016/j.chemphyslip.2015.06.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dispersions of multilamellar liposomes prepared from monounsaturated diacylphosphatidylcholines having 18-24 carbons and from varying amounts of cholesterol were studied by densitometry. Ideal mixing of the studied phosphatidylcholines with cholesterol in the fluid phase was observed. The temperature dependence of partial volumes of both phosphatidylcholines and cholesterol was determined. A slight decrease in the partial volume of cholesterol with the lengthening of the acyl chain of the host phosphatidylcholine was observed. By measuring the density of multilamellar liposomes of dinervonoylposphatidylcholine and cholesterol below the main phase transition temperature, the phase boundary between the solid ordered phase and the area of coexistence of the solid ordered and liquid ordered phases was detected. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1 / 8

页数：8

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