Matrix-free laser desorption-ionization with silver nanoparticle-enhanced steel targets

被引：65

作者：

Niziol, Joanna ^{[1
]}

Rode, Wojciech ^{[2
]}

Zielinski, Zbigniew ^{[2
]}

Ruman, Tomasz ^{[1
]}

机构：

[1] Rzeszow Univ Technol, Fac Chem, Bioorgan Chem Lab, PL-35959 Rzeszow, Poland

[2] M Nencki Inst Expt Biol, PL-02093 Warsaw, Poland

来源：

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 2013年 / 335卷

关键词：

Low molecular weight compounds; MALDI; Mass spectrometry; Matrix; Matrix-assisted laser desorption-ionization; Matrix-free LDI; Nanoparticles; SALDI; DESORPTION/IONIZATION MASS-SPECTROMETRY; MICROWAVE ENZYMATIC DIGESTION; THIN-LAYER-CHROMATOGRAPHY; GOLD NANOPARTICLES; MS ANALYSIS; CONCENTRATING PROBES; TITANIUM-DIOXIDE; PARTICLE MATRIX; SMALL MOLECULES; QUANTUM DOTS;

D O I：

10.1016/j.ijms.2012.10.009

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

Preparation is described of durable surface of cationic silver nanoparticles (AgNPs), covering commercial and modified MALDI targets, along with characterization of nanoparticles properties and examples of the use in MS analyses of various low molecular weight (LMW) organic compounds, including saccharides, amino acids, nucleosides, glycosides, sulfonic acids, aldehydes and nucleic bases. The new surface allowed higher sensitivity of detection, being attomoles for D-ribose. Examples of application of new Ag nanoparticle-enhanced target for analysis of biological samples, urine and blood serum, are also presented. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：22 / 32

页数：11

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