CaCl2 as a bifunctional reusable catalyst: diversity-oriented synthesis of 4H-pyran library under ultrasonic irradiation

被引：53

作者：

Safaei, Hamid Reza ^{[1
]}

Shekouhy, Mohsen ^{[1
,2
]}

Shirinfeshan, Athar ^{[1
]}

Rahmanpur, Sudabeh ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Appl Chem, Fac Sci, Shiraz Branch, Shiraz, Iran

[2] Islamic Azad Univ, Young Researchers Club, Shiraz Branch, Shiraz, Iran

来源：

MOLECULAR DIVERSITY | 2012年 / 16卷 / 04期

关键词：

Multi-component reactions; MCRs; Diversity-oriented synthesis; DOS; Ultrasound-promoted synthesis; Calcium chloride; 4H-pyrans; Combinatorial chemistry; ONE-POT SYNTHESIS; AQUEOUS-MEDIA; IONIC LIQUID; EFFICIENT SYNTHESIS; MULTICOMPONENT REACTIONS; 3-COMPONENT SYNTHESIS; ASSISTED SYNTHESIS; CALCIUM-CHLORIDE; GREEN SYNTHESIS; DERIVATIVES;

D O I：

10.1007/s11030-012-9392-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CaCl2 is applied as an efficient reusable and eco-friendly bifunctional catalyst for the one-pot three-component synthesis of 4H-pyrans under ultrasonic irradiation. A broad range of substrates including the aromatic and heteroaromatic aldehydes, indoline-2,3-dione (isatin) derivatives, acenaphthylene-1,2-dione (acenaphthenequinone) and 2, 2-dihydroxy-2H-indene-1,3-dione (ninhydrin) were condensed with carbonyl compounds possessing a reactive alpha-methylene group and alkylmalonates. All reactions are completed in short times, and the products are obtained in good to excellent yields. The catalyst could be recycled and reused several times without any loss of efficiency.

引用

页码：669 / 683

页数：15

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