Natural and Synthetic Coumarins with Effects on Inflammation

被引：107

作者：

Kirsch, Gilbert ^{[1
]}

Abdelwahab, Ahmed Bakr ^{[1
,2
]}

Chaimbault, Patrick ^{[1
]}

机构：

[1] ICPM, UMR 7565, Grp HeCRIN, SRSMC, 1 Blvd Arago, F-57070 Metz, France

[2] Natl Res Ctr, Chem Nat Cpds Dept, El Behoos St 33, Dokki 12622, Egypt

来源：

MOLECULES | 2016年 / 21卷 / 10期

关键词：

coumarins; furocoumarins; pyranocoumarins; inflammation; NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; ANTIINFLAMMATORY PROPERTIES; BIOLOGICAL EVALUATION; INHIBITORY-ACTIVITY; TNF-ALPHA; IN-VIVO; IMPERATORIN; MACROPHAGES; EXPRESSION;

D O I：

10.3390/molecules21101322

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this review, we will present the different aspects of coumarins and derivatives, from natural origins or synthetically prepared, and their action on inflammation. Coumarins and also furo-and pyranocoumarins are found in many different plants. These compounds are very often investigated for antioxidant properties. Other biological properties are also possible and anti-inflammation activity is one of these. As coumarins are also available quite easily via synthesis, natural ones can be prepared this way but derivatives with special substituents are also feasible. A review on the same topic appeared in 2004 and our contribution will take into account everything published since then.

引用

页数：13

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