Methylprednisolone inhibits Nogo-A protein expression after acute spinal cord injury

被引：0

作者：

Fu, Zhaozong ^{[1
]}

Lu, Hai ^{[1
]}

Jiang, Jianming ^{[1
]}

Jiang, Hui ^{[1
]}

Zhang, Zhaofei ^{[1
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Dept Spinal Surg, Guangzhou 510515, Guangdong, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2013年 / 8卷 / 05期

关键词：

neural regeneration; spinal cord injury; methylprednisolone; Nogo-A; oligodendrocyte; spinal cord pathology; myelonecrosis; weight-drop contusion; photographs-containing paper; neuroregeneration; MYELIN-ASSOCIATED GLYCOPROTEIN; CENTRAL-NERVOUS-SYSTEM; NEURITE GROWTH; AXONAL REGENERATION; RATS; RECOVERY; OLIGODENDROCYTES; IDENTIFICATION; THORACOLUMBAR; FRACTURES;

D O I：

10.3969/j.issn.1673-5374.2013.05.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Oligodendrocyte-produced Nogo-A has been shown to inhibit axonal regeneration. Methylprednisolone plays an effective role in treating spinal cord injury, but the effect of methylprednisolone on Nogo-A in the injured spinal cord remains unknown. The present study established a rat model of acute spinal cord injury by the weight-drop method. Results showed that after injury, the motor behavior ability of rats was reduced and necrotic injury appeared in spinal cord tissues, which was accompanied by increased Nogo-A expression in these tissues. After intravenous injection of high-dose rnethylprednisolone, although the pathology of spinal cord tissue remained unchanged, Nogo-A expression was reduced, but the level was still higher than normal. These findings implicate that methylprednisolone could inhibit Nogo-A expression, which could be a mechanism by which early high dose rnethylprednisolone infusion helps preserve spinal cord function after spinal cord injury.

引用

页码：404 / 409

页数：6

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