Cancer stem cells

被引：536

作者：

Yu, Zuoren ^{[1
]}

Pestell, Timothy G. ^{[3
]}

Lisanti, Michael P. ^{[3
]}

Pestell, Richard G. ^{[2
]}

机构：

[1] Tongji Univ, Res Ctr Translat Med, E Hosp, Sch Med, Shanghai 200120, Peoples R China

[2] Thomas Jefferson Univ, Dept Canc Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[3] Thomas Jefferson Univ, Dept Stem Cell Biol & Regenerat Med, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2012年 / 44卷 / 12期

关键词：

Cancer stem cells; Tumorigenesis; Relapse; Metastasis; MiRNA; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN BREAST-CANCER; SIGNALING PATHWAY; TUMOR-METASTASIS; MICRORNA; GROWTH; EXPRESSION; INVASION; IDENTIFICATION; MIGRATION;

D O I：

10.1016/j.biocel.2012.08.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer stem cells (CSCs) are a small subpopulation of cells within tumors with capabilities of self-renewal, differentiation, and tumorigenicity when transplanted into an animal host. A number of cell surface markers such as CD44, CD24, and CD133 are often used to identify and enrich CSCs. A regulatory network consisting of microRNAs and Wnt/beta-catenin, Notch, and Hedgehog signaling pathways controls CSC properties. The clinical relevance of CSCs has been strengthened by emerging evidence, demonstrating that CSCs are resistant to conventional chemotherapy and radiation treatment and that CSCs are very likely to be the origin of cancer metastasis. CSCs are believed to be an important target for novel anticancer drug discovery. Herein we summarize the current understanding of CSCs, with a focus on the role of miRNA and epithelial-mesenchymal transition (EMT), and discuss the clinical application of targeting CSCs for cancer treatment. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2144 / 2151

页数：8

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