Amelioration of influenza-induced pathology in mice by coinfection with Trichinella spiralis

被引:63
作者
Furze, RC
Hussell, T
Selkirk, ME
机构
[1] Univ London Imperial Coll Sci & Technol, Div Cell & Mol Biol, London SW7 2AZ, England
[2] Univ London Imperial Coll Sci & Technol, Kennedy Inst Rheumatol, London W6 8LM, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
D O I
10.1128/IAI.74.3.1924-1932.2006
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Illness due to respiratory virus infection is often induced by excessive infiltration of cells into pulmonary tissues, leading to airway occlusion. We show here that infection with Trichinella spiralis results in lower levels of tumor necrosis factor in bronchoalveolar lavage fluid and inhibits cellular recruitment into the airways of mice coinfected with influenza A virus. Infiltration of neutrophils and CD4(+) and CD8(+) lymphocytes was reduced, resulting in animals gaining weight more rapidly following the initial phase of infection. Influenza resulted in a generalized increase in vascular permeability in pulmonary tissues, and this was suppressed by parasite infection, although the effects were restricted to the early phase of trichinosis. Moreover, the number of cells producing interleukin-10 (IL-10), and the local levels of this cytokine, were reduced, suggesting that amelioration of pulmonary pathology by parasite infection occurs independently of IL-10 production.
引用
收藏
页码:1924 / 1932
页数:9
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