Facile synthesis of cetyltrimethylammonium bromide-loaded mesoporous silica nanoparticles for efficient inhibition of hepatocellular carcinoma cell proliferation

被引：18
作者：
Ai, Fulu [1 ]
Zhao, Guohua [1 ]
Lv, Wu [1 ]
Lin, Jie [1 ]
机构：
[1] China Med Univ, Dept Gen Surg, Canc Hosp, Liaoning Canc Hosp & Inst,VIP Ward, Shenyang 110042, Peoples R China
来源：
MATERIALS RESEARCH EXPRESS | 2020年 / 7卷 / 08期
关键词：
mesoporous silica nanoparticles; CTAB; cancer treatment; Human Hepatoma Cells; CHEMOTHERAPY; CAPTURE;
D O I：
10.1088/2053-1591/abad15
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
We report the synthesis of cetyltrimethylammonium bromide (CTAB)-loaded mesoporous silica nanoparticles (MSNs) as efficient anticancer agents. The chemical composition and structure, drug loading capacity, andin vitrocytotoxicity of CTAB-MSNs were analyzed. Our results reveal that CTAB-MSNs display a uniform pore structure, extensive surface area, and high drug-loading capacity, of approximately 37.2% by weight. The viability assessments showed that CTAB-MSNs exhibited superior human hepatoma (HepG2) cell killing compared to free CTAB. Therefore, CTAB-MSNs may have advantages over conventional cancer therapies.
引用
收藏
页数：5
相关论文
共 18 条
[1]   Hematological malignancies [J].
Brenner, MK .
FASEB JOURNAL, 1997, 11 (08) :640-648
[2]   Janus silver mesoporous silica nanobullets with synergistic antibacterial functions [J].
Chang, Zhi-min ;
Wang, Zheng ;
Lu, Meng-meng ;
Shao, Dan ;
Yue, Juan ;
Yang, Dian ;
Li, Ming-qiang ;
Dong, Wen-fei .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2017, 157 :199-206
[3]   Preparation of CTAB-loaded magnetic nanospheres for rapid bacterial capture and decontamination [J].
Chen, Guangjun ;
Li, Zeng ;
Wang, Xiaoke ;
Xie, Lijuan ;
Qi, Qinqin ;
Fang, Weijun .
MATERIALS LETTERS, 2014, 134 :290-294
[4]   Translation in solid cancer: are size-based response criteria an anachronism? [J].
Fernandes, M. ;
Rosel, D. ;
Brabek, J. .
CLINICAL & TRANSLATIONAL ONCOLOGY, 2015, 17 (01) :1-10
[5]   Synthesis and in vitro evaluation of quaternary ammonium derivatives of chlorambucil and melphalan, anticancer drugs designed for the chemotherapy of chondrosarcoma [J].
Giraud, I ;
Rapp, M ;
Maurizis, JC ;
Madelmont, JC .
JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (10) :2116-2119
[6]   Shape control of mesoporous silica nanomaterials templated with dual cationic surfactants and their antibacterial activities [J].
Hao, Nanjing ;
Chen, Xuan ;
Jayawardana, Kalana W. ;
Wu, Bin ;
Sundhoro, Madanodaya ;
Yan, Mingdi .
BIOMATERIALS SCIENCE, 2016, 4 (01) :87-91
[7]   MSN Anti-Cancer Nanomedicines: Chemotherapy Enhancement, Overcoming of Drug Resistance, and Metastasis Inhibition [J].
He, Qianjun ;
Shi, Jianlin .
ADVANCED MATERIALS, 2014, 26 (03) :391-411
[8]   An anticancer drug delivery system based on surfactant-templated mesoporous silica nanoparticles [J].
He, Qianjun ;
Shi, Jianlin ;
Chen, Feng ;
Zhu, Min ;
Zhang, Lingxia .
BIOMATERIALS, 2010, 31 (12) :3335-3346
[9]   Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular Carcinoma [J].
Hernandez-Gea, Virginia ;
Toffanin, Sara ;
Friedman, Scott L. ;
Llovet, Josep M. .
GASTROENTEROLOGY, 2013, 144 (03) :512-527
[10]   Influence of pore size of MCM-41 matrices on drug delivery rate [J].
Horcajada, P ;
Rámila, A ;
Pérez-Pariente, J ;
Vallet-Regí, M .
MICROPOROUS AND MESOPOROUS MATERIALS, 2004, 68 (1-3) :105-109
12