ATP synthase c-subunit ring as the channel of mitochondrial permeability transition: Regulator of metabolism in development and degeneration

被引：51
|
作者：
Mnatsakanyan, Nelli [1 ]
Jonas, Elizabeth Ann [1 ]
机构：
[1] Yale Univ, Dept Internal Med, Sect Endocrinol, New Haven, CT 06520 USA
来源：
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2020年 / 144卷
基金：
美国国家卫生研究院;
关键词：
Mitochondria; Apoptosis; Mitochondrial permeability transition pore; ATP synthase; PERIPHERAL BENZODIAZEPINE-RECEPTOR; CA-2&-INDUCED MEMBRANE TRANSITION; BETA-F1-ATPASE MESSENGER-RNA; MENTAL-RETARDATION PROTEIN; COMPRISE VDAC MOLECULES; LONG-TERM POTENTIATION; FRAGILE-X-SYNDROME; INNER MEMBRANE; CELL-DEATH; SYNAPTIC-TRANSMISSION;
D O I：
10.1016/j.yjmcc.2020.05.013
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The mitochondrial permeability transition pore (mPTP) or mitochondrial megachannel is arguably one of the most mysterious phenomena in biology today. mPTP has been at the center of ongoing extensive scientific research for the last several decades. In this review we will discuss recent advances in the field that enhance our understanding of the molecular composition of mPTP, its regulatory mechanisms and its pathophysiological role. We will describe our recent findings on the role of ATP synthase c-subunit ring as a central player in mitochondrial permeability transition and as an important metabolic regulator during development and in degenerative diseases.
引用
收藏
页码：109 / 118
页数：10
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