An efficient method for the synthesis of 2-thiazoleacetic acid N-sulfonyl amidines

被引：4

作者：

Il'kin, Vladimir G. ^{[1
]}

Berseneva, Vera S. ^{[1
]}

Slepukhin, Pavel A. ^{[1
,2
]}

Bakulev, Vasiliy A. ^{[1
]}

机构：

[1] Ural Fed Univ, 19 Mira St, Ekaterinburg 620002, Russia

[2] Russian Acad Sci, Ural Branch, Postovsky Inst Organ Synth, 22 S Kovalevskoi 20 Akad Skaya St, Ekaterinburg 620990, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2018年 / 54卷 / 12期

基金：

俄罗斯基础研究基金会;

关键词：

azides; thiazoles; 1,2,3,4-thiatriazoles; thioamides; cycloaddition; BIOLOGICAL EVALUATION; DERIVATIVES SYNTHESIS; THIAZOLE; AZIDES; 1,2,3-TRIAZOLES; CYCLIZATION; THIOAMIDES; CATALYST;

D O I：

10.1007/s10593-019-02407-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A three-step method was designed and developed on the basis of retrosynthetic analysis for the synthesis of hybrid molecules containing a thiazole ring and an N-sulfonyl amidine fragment, connected by a methylene linker. The mechanism of the last step involves the formation of intermediate 1,2,3,4-thiatriazoles and their transformation into the final products as a result of the elimination of molecular nitrogen and sulfur.

引用

页码：1153 / 1160

页数：8

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