Association of serum proprotein convertase subtilisin/kexin type 9 with carotid intima media thickness in hypertensive subjects

被引：57

作者：

Lee, Chan Joo ^{[1
]}

Lee, Yong-ho ^{[2
]}

Park, Sahng Wook ^{[1
]}

Kim, Kwang Joon ^{[2
]}

Park, Sungha ^{[3
,4
]}

Youn, Jong-Chan ^{[3
]}

Lee, Sang-Hak ^{[3
]}

Kang, Seok-Min ^{[3
]}

Jang, Yangsoo ^{[3
,4
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Biochem & Mol Biol,Brain Korea Project Med S, Inst Genet Sci,Integrated Genom Res Ctr Metab Reg, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul 120752, South Korea

[3] Yonsei Univ, Coll Med, Div Cardiol, Yonsei Cardiovasc Hosp, Seoul 120752, South Korea

[4] Yonsei Univ, Coll Med, Cardiovasc Genome Ctr, Yonsei Cardiovasc Hosp, Seoul 120752, South Korea

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2013年 / 62卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

PCSK9; Atherosclerosis; Carotid IMT (Intima-media thickness); CORONARY-HEART-DISEASE; LDL RECEPTORS; PCSK9; ATHEROSCLEROSIS; HYPERCHOLESTEROLEMIA; CHOLESTEROL; PREDICTION; DECREASES; INCREASE; RISK;

D O I：

10.1016/j.metabol.2013.01.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. The clinical significance of the measurement of serum PCSK9 (proprotein subtilisin kexin type 9) is not well defined. This study investigated the association between serum PCSK9 levels and atherosclerosis assessed by carotid intima media thickness (IMT) in hypertensive patients. Methods. A total of 126 hypertensive patients over the age of 45 were enrolled. The maximum carotid IMT (max-IMT) and the mean carotid IMT (mean-IMT) were measured at the time of enrollment. Clinical and laboratory parameters including serum PCSK9 were analyzed. Results. Patients were divided into tertiles based on serum PCSK9 levels. After adjusting for age, sex, total cholesterol, HDL-cholesterol and triglyceride, max-IMT was significantly increased in the highest tertile of serum PCSK9 (0.969 +/- 0.033 vs 0.959 +/- 0.033 vs 1.077 +/- 0.033 mm, respectively; P=0.026). Mean-IMT showed a tendency to increase across the tertile groups (0.773 +/- 0.025 vs 0.790 +/- 0.026 vs 0.856 +/- 0.025 mm, respectively; P=0.059). Multivariate regression analysis revealed that serum PCSK9 was independently associated with carotid IMT (max-IMT: beta=0.212, P=0.016; mean-IMT: beta=0.184, P=0.04). Conclusion. The present study is the first to report the association between serum PCSK9 levels and carotid IMT in hypertensive patients. These results suggest that serum PCSK9 may have a certain role in early pathogenesis of atherosclerosis. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：845 / 850

页数：6

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