Undressing the Fungal Cell Wall/Cell Membrane - the Antifungal Drug Targets

被引：39

作者：

Tada, Rui ^{[1
]}

Latge, Jean-Paul ^{[1
]}

Aimanianda, Vishukumar ^{[1
]}

机构：

[1] Inst Pasteur, Unite Aspergillus, F-75015 Paris, France

来源：

CURRENT PHARMACEUTICAL DESIGN | 2013年 / 19卷 / 20期

关键词：

Aspergillus fumigatus; Candida albicans; azole; echinocandin; cell wall; polysaccharide; chitin; glucan; mannan; antifungal drugs; ERGOSTEROL BIOSYNTHESIS PATHWAY; LIPOSOMAL AMPHOTERICIN-B; ASPERGILLUS-FUMIGATUS; CANDIDA-ALBICANS; CHITIN SYNTHASE; AZOLE RESISTANCE; GLUCAN SYNTHASE; IN-VITRO; PEPTIDOGLYCAN STRUCTURE; INVASIVE ASPERGILLOSIS;

D O I：

10.2174/1381612811319200012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Being external, the fungal cell wall plays a crucial role in the fungal life. By covering the underneath cell, it offers mechanical strength and acts as a barrier, thus protecting the fungus from the hostile environment. Chemically, this cell wall is composed of different polysaccharides. Because of their specific composition, the fungal cell wall and its underlying plasma membrane are unique targets for the development of drugs against pathogenic fungal species. The objective of this review is to consolidate the current knowledge on the antifungal drugs targeting the cell wall and plasma membrane, mainly of Aspergillus and Candida species - the most prevalent fungal pathogens, and also to present challenges and questions conditioning the development of new antifungal drugs targeting the cell wall.

引用

页码：3738 / 3747

页数：10

共 123 条

[1] TEMPERATURE-INDUCED MODIFICATIONS OF GLYCOSPHINGOLIPIDS IN PLASMA-MEMBRANES OF NEUROSPORA-CRASSA [J].

AARONSON, LR ;

MARTIN, CE .

BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 735 (02) :252-258

[2] Problems and hopes in the development of drugs targeting the fungal cell wall [J].

Aimanianda, Vishukumar ;

Latge, Jean-Paul .

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2010, 8 (04) :359-364

[3] Cell wall active antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL-15G256 -: III.: Biological properties of 15G256γ [J].

Albaugh, D ;

Albert, G ;

Bradford, P ;

Cotter, V ;

Froyd, J ;

Gaughran, J ;

Kirsch, DR ;

Lai, M ;

Rehnig, A ;

Sieverding, E ;

Silveriman, S .

JOURNAL OF ANTIBIOTICS, 1998, 51 (03) :317-322

[4] Ergosterol biosynthesis pathway in Aspergillus fumigatus [J].

Alcazar-Fuoli, Laura ;

Mellado, Emilia ;

Garcia-Effron, Guillermo ;

Lopez, Jordi R. ;

Grimalt, Joan O. ;

Cuenca-Estrella, J. Manuel ;

Rodriguez-Tudela, Juan L. .

STEROIDS, 2008, 73 (03) :339-347

[5] Evolution of antifungal-drug resistance: Mechanisms and pathogen fitness [J].

Anderson, JB .

NATURE REVIEWS MICROBIOLOGY, 2005, 3 (07) :547-556

[6] Posaconazole: A New Antifungal Weapon [J].

Aperis, Georgios ;

Alivanis, Polichronis .

REVIEWS ON RECENT CLINICAL TRIALS, 2011, 6 (03) :204-219

[7] Establishing in vitro-in vivo correlations for Aspergillus fumigatus:: the challenge of azoles versus echinocandins [J].

Arendrup, Maiken Cavling ;

Perkhofer, Susanne ;

Howard, Susan J. ;

Garcia-Effron, Guillermo ;

Vishukumar, Aimanianda ;

Perlin, David ;

Lass-Floerl, Cornelia .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (10) :3504-3511

[8] Development of Azole Resistance in Aspergillus fumigatus during Azole Therapy Associated with Change in Virulence [J].

Arendrup, Maiken Cavling ;

Mavridou, Eleftheria ;

Mortensen, Klaus Leth ;

Snelders, Eveline ;

Frimodt-Moller, Niels ;

Khan, Humara ;

Melchers, Willem J. G. ;

Verweij, Paul E. .

PLOS ONE, 2010, 5 (04)

[9]

Armstrong-James D, 2012, CURR OPIN MICROBIOL

[10] Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast [J].

Bagnat, M ;

Keränen, S ;

Shevchenko, A ;

Simons, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3254-3259

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