Familial Mediterranean Fever with Onset at 66 Years of Age

被引：8

作者：

Inoue, Keita ^{[1
]}

Torii, Kazuhiro ^{[1
]}

Yoda, Aya ^{[1
]}

Kadota, Koichiro ^{[1
]}

Nakamichi, Seiko ^{[1
]}

Obata, Yoko ^{[2
,3
]}

Nishino, Tomoya ^{[3
]}

Migita, Kiyoshi ^{[4
]}

Kawakami, Atsushi ^{[5
]}

Ozono, Yoshiyuki ^{[1
]}

机构：

[1] Nagasaki Univ, Sch Med, Dept Gen Med, Nagasaki, Japan

[2] Nagasaki Univ Hosp, Med Educ Dev Ctr, Nagasaki, Japan

[3] Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki, Japan

[4] Nagasaki Med Ctr, Natl Hosp Org, Clin Res Ctr, Nagasaki, Japan

[5] Nagasaki Univ, Sch Med, Dept Immunol & Rheumatol, Nagasaki, Japan

来源：

INTERNAL MEDICINE | 2012年 / 51卷 / 18期

关键词：

abdominal pain; familial Mediterranean fever; febrile episodes; MEFV gene; 3 JAPANESE PATIENTS; MUTATION; PATIENT; GENE; DISEASE; VARIANT; FMF;

D O I：

10.2169/internalmedicine.51.6846

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The patient was a 68-year-old woman who had experienced recurrent febrile episodes since 66 years of age. Despite various examinations and treatments, the etiology remained unclear. Further examinations following another referral failed to uncover the cause. Therefore, despite her age, it was presumed that she had familial Mediterranean fever. An analysis of the familial Mediterranean fever (MEFV) gene detected heterozygous L110P, E148Q, and R202Q mutations. No further febrile episodes occurred after colchicine treatment was initiated. Familial Mediterranean fever presenting in patients in their sixties is extremely rare.

引用

页码：2649 / 2653

页数：5

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