ZBTB7A links tumor metabolism to myeloid differentiation

被引：3
|
作者：
Monte, Enric Redondo [1 ,2 ,3 ]
Kerbs, Paul [1 ,2 ,3 ]
Greif, Philipp A. [1 ,2 ,3 ]
机构：
[1] Ludwig Maximilians Univ Munchen, Dept Med 3, Univ Hosp, Munich, Germany
[2] German Canc Consortium, Partner Site, Munich, Germany
[3] German Canc Res Ctr, Heidelberg, Germany
来源：
EXPERIMENTAL HEMATOLOGY | 2020年 / 87卷
关键词：
REPRESSION; PATHWAY; MITOCHONDRIAL; CHECKPOINT; MUTATIONS; LANDSCAPE; GLUCOSE; LRF;
D O I：
10.1016/j.exphem.2020.05.010
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
ZBTB7A is a transcription factor that regulates all three branches of hematopoietic differentiation while repressing the expression of key glycolytic enzymes and glucose transporters. Here, we propose that ZBTB7A acts as a link between differentiation and metabolism, two interconnected cellular processes. In particular, ZBTB7A can activate or repress metabolic programs necessary for the differentiation of specific cell lineages while controlling key pathways such as Notch signaling. Finally, the dual role of ZBTB7A has implications for the treatment of myeloid malignancies, where the block of differentiation could potentially be overcome by metabolic therapies with low toxicity. (C) 2020 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc.
引用
收藏
页码：20 / +
页数：6
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