Genetic Risk Factors for Ischemic and Hemorrhagic Stroke

被引：102

作者：

Chauhan, Ganesh ^{[1
,2
,3
]}

Debette, Stephanie ^{[1
,2
,4
]}

机构：

[1] Bordeaux Populat Hlth Res Ctr, INSERM, U1219, 146 Rue Leo Saignat, F-33000 Bordeaux, France

[2] Univ Bordeaux, Bordeaux, France

[3] Indian Inst Sci, Ctr Brain Res, Bangalore, Karnataka, India

[4] Bordeaux Univ Hosp, Dept Neurol, Bordeaux, France

来源：

CURRENT CARDIOLOGY REPORTS | 2016年 / 18卷 / 12期

基金：

欧盟地平线“2020”;

关键词：

Stroke; Ischemic stroke; Hemorrhagic stroke; Genome-wide association studies; Multifactorial; GENOME-WIDE ASSOCIATION; EHLERS-DANLOS-SYNDROME; RETINAL ARTERIOLAR TORTUOSITY; SMALL VESSEL DISEASE; SUSCEPTIBILITY LOCI; CEREBRAL-HEMORRHAGE; ATRIAL-FIBRILLATION; LACTIC-ACIDOSIS; AMYLOID ANGIOPATHY; COL4A1; MUTATIONS;

D O I：

10.1007/s11886-016-0804-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Understanding the genetic risk factors for stroke is an essential step to decipher the underlying mechanisms, facilitate the identification of novel therapeutic targets, and optimize the design of prevention strategies. A very small proportion of strokes are attributable to monogenic conditions, the vast majority being multifactorial, with multiple genetic and environmental risk factors of small effect size. Genome-wide association studies and large international consortia have been instrumental in finding genetic risk factors for stroke. While initial studies identified risk loci for specific stroke subtypes, more recent studies also revealed loci associated with all stroke and all ischemic stroke. Risk loci for ischemic stroke and its subtypes have been implicated in atrial fibrillation (PITX2 and ZFHX3), coronary artery disease (ABO, chr9p21, HDAC9, and ALDH2), blood pressure (ALDH2 and HDAC9), pericyte and smooth muscle cell development (FOXF2), coagulation (HABP2), carotid plaque formation (MMP12), and neuro-inflammation (TSPAN2). For hemorrhagic stroke, two loci (APOE and PMF1) have been identified.

引用

页数：11

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