The differential associations between HDL, non-HDL and total cholesterols and atherosclerotic calcium deposits in multiple vascular beds

被引:26
作者
Allison, Matthew A. [1 ,2 ]
Pavlinac, Patricia [3 ]
Wright, C. Michael [2 ]
机构
[1] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
[3] Colgate Univ, New York, NY USA
关键词
Atherosclerosis; Cholesterol; Calcium; Peripheral vascular;
D O I
10.1016/j.atherosclerosis.2006.10.006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The purpose of this study was to determine the magnitude of associations between four different cholesterol measures and systemic atherosclerotic calcification. Methods: One thousand and seventy-eight consecutive patients were evaluated by electron beam computed tomography for the extent of calcified atherosclerosis in the carotids, coronaries, thoracic aorta, abdominal aorta, renals and iliacs, as well as the mitral and aortic annuli. HDL, non-HDL and total cholesterol were measured using the Cholestec LDX system. Results: Overall, the prevalence of calcium in the carotids, coronaries, thoracic aorta, abdominal aorta, iliacs, renals, mitral annulus and aortic annulus was 31.6, 58.7, 40.5, 55.0, 16.8, 57.0, 8.3 and 23.6%, respectively. After multivariable adjustment, a 1-S.D. interval in the total to HDL cholesterol ratio in men was significantly associated with 36 and 29% higher odds for any calcium in the abdominal aorta and iliac arteries, respectively. In women, this same interval was significantly associated with odds ratios of 1.66 and 1.41 for the presence of any calcium in the thoracic and abdominal aorta, respectively. Conclusion: Measurement of HDL and non-HDL cholesterols, as well as calculation of the total cholesterol to HDL ratio, may provide a practical means for stratifying the risk for extra-coronary calcified atherosclerosis. (C) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:E87 / E94
页数:8
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