Synthesis and study of the antidepressant activity of novel 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives

被引：14
|
作者：
Sun, Xian-Yu [1 ]
He, Xian-Jing [1 ]
Pan, Chun-Yuan [1 ]
Liu, Yan-Peng [1 ]
Zou, Yun-Peng [1 ]
机构：
[1] Heilongjiang Bayi Agr Univ, Coll Anim Sci & Tech, Daqing 163319, Heilongjiang, Peoples R China
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 11期
关键词：
Tetrazole; Quinoline; Forced swimming test; Tail suspension test; DEPRESSION; PREVALENCE;
D O I：
10.1007/s00044-011-9922-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In this study, a novel series of 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives was synthesized as potential antidepressant agents. Their antidepressant activities were evaluated by the forced swimming test and tail suspension test models. The pharmacological results showed that 7-(4-fluorobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 7j was found possessing strong activity in the both tests, especially in the FTS model, which was considered as the most promising compounds in this study.
引用
收藏
页码：3692 / 3698
页数：7
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