Impact of rapid influenza PCR testing on hospitalization and antiviral use: A retrospective cohort study

被引：43

作者：

Chu, Helen Y. ^{[1
]}

Englund, Janet A. ^{[2
]}

Huang, Dandi ^{[1
]}

Scott, Emily ^{[1
]}

Chan, Jeanne D. ^{[3
]}

Jain, Rupali ^{[3
]}

Pottinger, Paul S. ^{[1
]}

Lynch, John B. ^{[1
]}

Dellit, Timothy H. ^{[1
]}

Jerome, Keith R. ^{[4
]}

Kuypers, Jane ^{[4
]}

机构：

[1] Univ Washington, Dept Med, Seattle, WA 98195 USA

[2] Seattle Childrens Hosp, Dept Pediat, Seattle, WA USA

[3] Univ Washington, Dept Pharm, Seattle, WA 98195 USA

[4] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA

来源：

JOURNAL OF MEDICAL VIROLOGY | 2015年 / 87卷 / 12期

基金：

美国国家卫生研究院;

关键词：

influenza; PCR; oseltamivir; infection control; RESPIRATORY VIRUS; CONTROLLED-TRIAL; DIAGNOSIS; MANAGEMENT; CHILDREN; ASSAYS;

D O I：

10.1002/jmv.24279

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Rapid PCR-based influenza tests are increasingly used as point-of-care diagnostics in hospitals and clinics. To our knowledge, no prior studies have described clinical outcomes with implementation of rapid PCR-based influenza tests in hospitalized adult inpatients. Electronic medical records were used to assess differences in laboratory testing time and antiviral use among a subset of 175 consecutive adult inpatients tested for influenza in two respiratory seasons before and after implementation of rapid PCR-based influenza testing at an academic medical center. Of the 350 hospitalized inpatients included in this analysis, 96 (27%) were over 65 years of age and 308 (88%) had a comorbid condition. The overall time to result decreased significantly from 25.2 to 1.7hr (P<0.001) after implementation of rapid PCR-based influenza testing. Among influenza-negative patients, the frequency of oseltamivir initiation remained unchanged (before: 43% vs. after: 45%; P=0.60), though the median duration of oseltamivir was significantly decreased from 1.1 to 0.0 days (P<0.001). By providing an earlier result to clinicians, rapid PCR-based influenza tests may decrease unnecessary antiviral use among adult inpatients who test negative for influenza. J. Med. Virol. 87:2021-2026, 2015. (c) 2015 Wiley Periodicals, Inc.

引用

页码：2021 / 2026

页数：6

共 11 条

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