The serotonin 1A receptor gene in mood disorders: a tale of missed opportunities

被引:1
作者
Sand, Philipp G. [1 ]
机构
[1] Univ Regensburg, Dept Psychiat & Psychotherapy, D-93053 Regensburg, Germany
关键词
5-HT1A; Mood disorders; Association; MAJOR DEPRESSIVE DISORDER; RISK-FACTORS; HTR1A GENE; ASSOCIATION; 5-HT1A; SUICIDE; ANXIETY; POLYMORPHISMS; METAANALYSIS; VARIANT;
D O I
10.1007/s00406-012-0381-0
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The role of the C-1019G variant in conferring susceptibility to mood disorders is an object of ongoing debate. In their recent meta-analysis of case-control investigations, Kishi and coworkers have sought to clarify the issue by pooling earlier results. Whether a claimed effect of this variant can be upheld, however, is questionable in view of numerous artefacts.
引用
收藏
页码:445 / 447
页数:3
相关论文
共 23 条
[1]   Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression [J].
Anttila, S. ;
Huuhka, K. ;
Huuhka, M. ;
Rontu, R. ;
Hurme, M. ;
Leinonen, E. ;
Lehtima, T. .
JOURNAL OF NEURAL TRANSMISSION, 2007, 114 (08) :1065-1068
[2]   Analysis of structural polymorphisms and C-1018G promoter variant of the 5-HT1A receptor gene as putative risk factors in major depression [J].
Arias, B ;
Arranz, MJ ;
Gasto, C ;
Catalan, R ;
Pintor, L ;
Gutierrez, B ;
Kerwin, RW ;
Fananas, L .
MOLECULAR PSYCHIATRY, 2002, 7 (09) :930-932
[3]   Poor replication of candidate genes for major depressive disorder using genome-wide association data [J].
Bosker, F. J. ;
Hartman, C. A. ;
Nolte, I. M. ;
Prins, B. P. ;
Terpstra, P. ;
Posthuma, D. ;
van Veen, T. ;
Willemsen, G. ;
DeRijk, R. H. ;
de Geus, E. J. ;
Hoogendijk, W. J. ;
Sullivan, P. F. ;
Penninx, B. W. ;
Boomsma, D. I. ;
Snieder, H. ;
Nolen, W. A. .
MOLECULAR PSYCHIATRY, 2011, 16 (05) :516-532
[4]   Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study [J].
Brezo, J. ;
Bureau, A. ;
Merette, C. ;
Jomphe, V. ;
Barker, E. D. ;
Vitaro, F. ;
Hebert, M. ;
Carbonneau, R. ;
Tremblay, R. E. ;
Turecki, G. .
MOLECULAR PSYCHIATRY, 2010, 15 (08) :831-843
[5]   Identification of New Putative Susceptibility Genes for Several Psychiatric Disorders by Association Analysis of Regulatory and Non-Synonymous SNPs of 306 Genes Involved in Neurotransmission and Neurodevelopment [J].
Gratacos, Monica ;
Costas, Javier ;
de Cid, Rafael ;
Bayes, Monica ;
Gonzalez, Juan R. ;
Baca-Garcia, Enrique ;
de Diego, Yolanda ;
Fernandez-Aranda, Fernando ;
Fernandez-Piqueras, Jose ;
Guitart, Miriam ;
Martin-Santos, Rocio ;
Martorell, Lourdes ;
Menchon, Jose M. ;
Roca, Miquel ;
Saiz-Ruiz, Jeronimo ;
Sanjuan, Julio ;
Torrens, Marta ;
Urretavizcaya, Mikel ;
Valero, Joaquin ;
Vilella, Elisabet ;
Estivill, Xavier ;
Carracedo, Angel .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2009, 150B (06) :808-816
[6]   Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders [J].
Hettema, J. M. ;
An, S. S. ;
van den Oord, E. J. C. G. ;
Neale, M. C. ;
Kendler, K. S. ;
Chen, X. .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2008, 147B (05) :661-666
[7]   Association study of serotonin pathway genes in attempted suicide [J].
Judy, Jennifer T. ;
Seifuddin, Fayaz ;
Mahon, Pamela B. ;
Huo, Yuqing ;
Goes, Fernando S. ;
Jancic, Dubravka ;
Schweizer, Barbara ;
Mondimore, Francis M. ;
MacKinnon, Dean F. ;
DePaulo, J. Raymond, Jr. ;
Gershon, Elliot S. ;
McMahon, Francis J. ;
Cutler, David J. ;
Zandi, Peter P. ;
Potash, James B. ;
Willour, Virginia L. .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2012, 159B (01) :112-119
[8]   Effect of 5-HT1A Gene Polymorphisms on Antidepressant Response in Major Depressive Disorder [J].
Kato, Masaki ;
Fukuda, Tsuyoshi ;
Wakeno, Masataka ;
Okugawa, Gaku ;
Takekita, Yoshiteru ;
Watanabe, Syunsuke ;
Yamashita, Megumi ;
Hosoi, Yuka ;
Azuma, Junichi ;
Kinoshita, Toshihiko ;
Serretti, Alessandro .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2009, 150B (01) :115-123
[9]   The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder [J].
Kishi, Taro ;
Yoshimura, Reiji ;
Fukuo, Yasuhisa ;
Okochi, Tomo ;
Matsunaga, Shinji ;
Umene-Nakano, Wakako ;
Nakamura, Jun ;
Serretti, Alessandro ;
Correll, Christoph U. ;
Kane, John M. ;
Iwata, Nakao .
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2013, 263 (02) :105-118
[10]   Serotonin 1A receptor gene, schizophrenia and bipolar disorder: An association study and meta-analysis [J].
Kishi, Taro ;
Okochi, Tomo ;
Tsunoka, Tomoko ;
Okumura, Takenori ;
Kitajima, Tsuyoshi ;
Kawashima, Kunihiro ;
Yamanouchi, Yoshio ;
Kinoshita, Yoko ;
Naitoh, Hiroshi ;
Inada, Toshiya ;
Kunugi, Hiroshi ;
Kato, Tadafumi ;
Yoshikawa, Takeo ;
Ujike, Hiroshi ;
Ozaki, Norio ;
Iwata, Nakao .
PSYCHIATRY RESEARCH, 2011, 185 (1-2) :20-26