RNA-Mediated Regulation in Pathogenic Bacteria

被引：125

作者：

Caldelari, Isabelle ^{[1
]}

Chao, Yanjie ^{[2
,3
]}

Romby, Pascale ^{[1
]}

Vogel, Joerg ^{[2
,3
]}

机构：

[1] Univ Strasbourg, Architecture & React ARN, CNRS, IBMC, F-67084 Strasbourg, France

[2] Univ Wurzburg, IMIB, D-97080 Wurzburg, Germany

[3] Univ Wurzburg, Zentrum Infekt Forsch ZINF, D-97080 Wurzburg, Germany

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2013年 / 3卷 / 09期

关键词：

STAPHYLOCOCCUS-AUREUS RNAIII; CARBON CATABOLITE REPRESSION; CRC GLOBAL REGULATOR; MESSENGER-RNA; ANTISENSE RNA; TRANSCRIPTIONAL LANDSCAPE; SIGNAL-TRANSDUCTION; CONTROLS EXPRESSION; PSEUDOMONAS-PUTIDA; CODING SEQUENCE;

D O I：

10.1101/cshperspect.a010298

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Pathogenic bacteria possess intricate regulatory networks that temporally control the production of virulence factors, and enable the bacteria to survive and proliferate after host infection. Regulatory RNAs are now recognized as important components of these networks, and their study may not only identify new approaches to combat infectious diseases but also reveal new general control mechanisms involved in bacterial gene expression. In this review, we illustrate the diversity of regulatory RNAs in bacterial pathogens, their mechanism of action, and how they can be integrated into the regulatory circuits that govern virulence-factor production.

引用

页数：21

共 133 条

[21] Th GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs [J].