Long Non-Coding RNA in Vascular Disease and Aging

被引：27

作者：

Bink, Diewertje, I ^{[1
]}

Lozano-Vidal, Noelia ^{[1
]}

Boon, Reinier A. ^{[1
,2
,3
]}

机构：

[1] Vrije Univ Amsterdam, Dept Physiol, Amsterdam Cardiovasc Sci, Amsterdam UMC, NL-1081 HV Amsterdam, Netherlands

[2] Goethe Univ, Inst Cardiovasc Regenerat, D-60596 Frankfurt, Germany

[3] German Ctr Cardiovasc Res DZHK, Partner Site Rhein Main, D-13347 Berlin, Germany

来源：

NON-CODING RNA | 2019年 / 5卷 / 01期

基金：

欧洲研究理事会;

关键词：

aging; vascular disease; lncRNA; CORONARY-ARTERY-DISEASE; MUSCLE-CELL PROLIFERATION; AGE-DEPENDENT IMPAIRMENT; GENOME-WIDE ASSOCIATION; LNCRNA-MIAT; ANRIL EXPRESSION; H19; MEG3; SUSCEPTIBILITY; GAS5;

D O I：

10.3390/ncrna5010026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiovascular diseases are the most prominent cause of death in Western society, especially in the elderly. With the increasing life expectancy, the number of patients with cardiovascular diseases will rise in the near future, leading to an increased healthcare burden. There is a need for new therapies to treat this growing number of patients. The discovery of long non-coding RNAs has led to a novel group of molecules that could be considered for their potential as therapeutic targets. This review presents an overview of long non-coding RNAs that are regulated in vascular disease and aging and which might therefore give insight into new pathways that could be targeted to diagnose, prevent, and/or treat vascular diseases.

引用

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