Iron-Catalyzed Difluoromethylation of Arylzincs with Difluoromethyl 2-Pyridyl Sulfone

被引：178

作者：

Miao, Wenjun ^{[1
]}

Zhao, Yanchuan ^{[1
]}

Ni, Chuanfa ^{[1
]}

Gao, Bing ^{[1
]}

Zhang, Wei ^{[1
]}

Hu, Jinbo ^{[1
]}

机构：

[1] Univ Chinese Acad Sci, Chinese Acad Sci, Key Lab Organofluorine Chem, Ctr Excellence Mol Synth,Shanghai Inst Organ Chem, 345 Ling Ling Rd, Shanghai 200032, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 140卷 / 03期

基金：

中国国家自然科学基金;

关键词：

COPPER-MEDIATED DIFLUOROMETHYLATION; RADICAL FLUOROALKYLATION; GEM-DIFLUOROOLEFINATION; FLUORINATED SULFONES; COUPLING REACTIONS; ARYLBORONIC ACIDS; ALKYL-HALIDES; ARYL HALIDES; BASE-METAL; ACTIVATION;

D O I：

10.1021/jacs.7b11976

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the first iron-catalyzed difluoromethylation of arylzincs with difluoromethyl 2-pyridyl sulfone via selective C-S bond cleavage. This method employs the readily available, liench-stable fluoroalkyl sulfone reagent and inexpensive iron. catalyst, allowing facile access to structurally diverse difluoromethylated arenes at low temperatures. The experiment employing a radical clock indicates the involvement of radical species in this iron-catalyzed difluoromethylation process.

引用

页码：880 / 883

页数：4

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