Inhibitory Glycine Receptors: An Update

被引:137
作者
Dutertre, Sebastien [2 ]
Becker, Cord-Michael [3 ]
Betz, Heinrich [1 ,4 ]
机构
[1] Max Planck Inst Med Res, D-69120 Heidelberg, Germany
[2] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
[3] Univ Erlangen Nurnberg, Inst Biochem, D-91054 Erlangen, Germany
[4] Max Planck Inst Expt Med, Dept Mol Neurobiol, D-37075 Gottingen, Germany
关键词
GATED ION-CHANNEL; RAT SPINAL-CORD; DORSAL HORN NEURONS; BETA-SUBUNIT; LIGAND-BINDING; CHROMOSOMAL LOCALIZATION; GABA(A) RECEPTOR; ALPHA-1; SUBUNIT; MOLECULAR DETERMINANTS; FUNCTIONAL EXPRESSION;
D O I
10.1074/jbc.R112.408229
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Strychnine-sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brainstem, and other regions of the mammalian central nervous system. In this minireview, we summarize our current view of the structure, ligand-binding sites, and chloride channel of these receptors and discuss recently emerging functions of distinct GlyR isoforms. GlyRs not only regulate the excitability of motor and afferent sensory neurons, including pain fibers, but also are involved in the processing of visual and auditory signals. Hence, GlyRs constitute promising targets for the development of therapeutically useful compounds.
引用
收藏
页码:40216 / 40223
页数:8
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