Production of the biomimetic small diameter blood vessels for cardiovascular tissue engineering

被引：24

作者：

Aydogdu, Mehmet Onur ^{[1
,2
]}

Chou, Joshua ^{[3
]}

Altun, Esra ^{[1
,2
]}

Ekren, Nazmi ^{[1
,4
]}

Cakmak, Selami ^{[5
]}

Eroglu, Mehmet ^{[6
]}

Osman, Asila A. ^{[6
]}

Kutlu, Ozlem ^{[7
,8
]}

Oner, Ebru Toksoy ^{[9
]}

Avsar, Gulben ^{[9
]}

Oktar, Faik Nuzhet ^{[1
,9
]}

Yilmaz, Ismail ^{[10
]}

Gunduz, Oguzhan ^{[1
,2
]}

机构：

[1] Marmara Univ, Dept Met & Mat Engn, Adv Nanomat Res Lab, Goztepe Campus, TR-34722 Istanbul, Turkey

[2] Marmara Univ, Inst Pure & Appl Sci, Dept Met & Mat Engn, Sci, Istanbul, Turkey

[3] Univ Technol Sydney, Sch Med & Mol Sci, Adv Tissue Regenerat & Drug Delivery Grp, Sydney, NSW, Australia

[4] Marmara Univ, Fac Technol, Dept Elect & Elect Engn, Istanbul, Turkey

[5] Acibadem Kadikoy Hosp, Orthoped & Traumatol Clin, Istanbul, Turkey

[6] Marmara Univ, Dept Chem Engn, Fac Engn, Istanbul, Turkey

[7] Sabanci Univ, Nanotechnol Res & Applicat Ctr, Istanbul, Turkey

[8] Sabanci Univ, EFSUN Ctr Excellence Funct Surfaces & Interfaces, Istanbul, Turkey

[9] Marmara Univ, Fac Engn, Dept Bioengn, Istanbul, Turkey

[10] Istanbul Sultan Abdulhamid Han Training Hosp, Pathol Dept, Istanbul, Turkey

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2019年 / 68卷 / 05期

关键词：

Cardiovascular tissue engineering; collagen; electrospinning; ethyl cellulose; polycaprolactone; SCAFFOLD; PROLIFERATION; FABRICATION; NANOFIBERS; HEPARIN; PATIENT; GRAFTS;

D O I：

10.1080/00914037.2018.1443930

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A novel biomimetic vascular graft scaffolds were produced by electrospinning method with the most superior characteristics to be a proper biomimetic small diameter blood vessel using Polycaprolactone(PCL), Ethyl Cellulose(EC) and Collagen Type-1 were used to create the most convenient synergy of a natural and synthetic polymer to achieve similarity to native small diameter blood vessels. Scanning Electron Microscopy(SEM), Fourier Transform Infrared Spectroscopy(FTIR), Differential Scanning Calorimetry Analysis(DSC), tensile measurement tests, and in-vitro and in-vivo applications were performed. Results indicated significant properties such as having 39.33 nm minimum, 104.98 nm average fiber diameter, 3.2 MPa young modulus and 135% relative cell viability. [GRAPHICS] .

引用

页码：243 / 255

页数：13

共 43 条

[1] Development of thrombus-resistant and cell compatible crimped polyethylene terephthalate cardiovascular grafts using surface co-immobilized heparin and collagen [J].