Phosphodiesterase 10A inhibition attenuates sleep deprivation-induced deficits in long-term fear memory

被引：11
作者：
Guo, Lengqiu [1 ,2 ,3 ]
Guo, Zhuangli [4 ]
Luo, Xiaoqing [3 ]
Liang, Rui [3 ]
Yang, Shui [3 ]
Ren, Haigang [3 ]
Wang, Guanghui [1 ,2 ]
Zhen, Xuechu [1 ,2 ]
机构：
[1] Soochow Univ, Coll Pharmaceut Sci, Jiangsu Key Lab Translat Res & Therapy Neuropsych, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China
[2] Soochow Univ, Coll Pharmaceut Sci, Dept Pharmacol, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China
[3] Suzhou Hlth Coll, Coll Pharmaceut Sci, 28 Kehua Rd, Suzhou 215009, Jiangsu, Peoples R China
[4] Qingdao Univ, Dept Rehabil Med, Affiliated Hosp, 16 Jiangsu Rd, Qingdao 266003, Shandong, Peoples R China
来源：
NEUROSCIENCE LETTERS | 2016年 / 635卷
基金：
美国国家科学基金会;
关键词：
REM sleep deprivation; Fear memory; Phosphodiesterase-10; POTENTIATED STARTLE; REM-SLEEP; PROTEIN-SYNTHESIS; AMYGDALA; CONSOLIDATION; HIPPOCAMPUS; STRIATUM; LESIONS; PDE10A; CAMP;
D O I：
10.1016/j.neulet.2016.10.017
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Sleep, particularly rapid eye movement (REM) sleep, is implicated in the consolidation of emotional memories. In the present study, we investigated the protective effects of a phosphodiesterase 10A (PDE10A) inhibitor MP-10 on deficits in long-term fear memory induced by REM sleep deprivation (REM-SD). REM-SD caused deficits in long-term fear memory, however, MP-10 administration ameliorated the deleterious effects of REM-SD on long term fear memory. Brain-derived neurotropic factor (BDNF) and phosphorylated CAMP response element-binding protein (pCREB) were altered in specific brain regions associated with learning and memory in REM-SD rats. Accordingly, REM-SD caused a significant decrease of pCREB in hippocampus and striatum and a significant decrease of BDNF in the hippocampus, striatum and amygdala, however, MP-10 reversed the effects of REM-SD in a dose-dependent manner. Our findings suggest that REM-SD disrupts the consolidation of long-term fear memory and that administration of MP-10 protects the REM-SD-induced deficits in fear memory, which may be due to the MP-10-induced expression of BDNF in the hippocampus, striatum and amygdala, and phosphorylation of CREB in the hippocampus and striatum. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：44 / 50
页数：7
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