Treatment of gastric cancer cells with nonthermal atmospheric plasma generated in water

被引：30

作者：

Chen, Zhitong ^{[1
]}

Lin, Li ^{[1
]}

Cheng, Xiaoqian ^{[1
]}

Gjika, Eda ^{[1
]}

Keidar, Michael ^{[1
]}

机构：

[1] George Washington Univ, Dept Mech & Aerosp Engn, Washington, DC 20052 USA

来源：

BIOINTERPHASES | 2016年 / 11卷 / 03期

基金：

美国国家科学基金会;

关键词：

BARRIER DISCHARGE PLASMA; APOPTOSIS; PROTEIN; LIQUID; NO;

D O I：

10.1116/1.4962130

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Nonthermal atmospheric plasma ( NTAP) can be applied to living tissues and cells as a novel technology for cancer therapy. The authors report on a NTAP argon solution generated in deionized ( DI) water for treating human gastric cancer cells ( NCI-N87). Our findings show that the plasma generated in DI water with 30-min duration has the strongest effect on apoptosis in precultured human gastric cancer cells. This result can be attributed to the presence of reactive oxygen species ( ROS) and reactive nitrogen species ( RNS) produced in water during treatment. Furthermore, the data show that the elevated levels of RNS may play a more significant role than ROS in the rate of cell death. (C) 2016 American Vacuum Society.

引用

页数：5

共 41 条

[1] Plasma-activated medium induces A549 cell injury via a spiral apoptotic cascade involving the mitochondrial-nuclear network [J].

Adachi, Tetsuo ;

Tanaka, Hiromasa ;

Nonomura, Saho ;

Hara, Hirokazu ;

Kondo, Shin-ichi ;

Hod, Masaru .

FREE RADICAL BIOLOGY AND MEDICINE, 2015, 79 :28-44

[2] Cold Atmospheric Plasma (CAP) Changes Gene Expression of Key Molecules of the Wound Healing Machinery and Improves Wound Healing In Vitro and In Vivo [J].

Arndt, Stephanie ;

Unger, Petra ;

Wacker, Eva ;

Shimizu, Tetsuji ;

Heinlin, Julia ;

Li, Yang-Fang ;

Thomas, Hubertus M. ;

Morfill, Gregor E. ;

Zimmermann, Julia L. ;

Bosserhoff, Anja-Katrin ;

Karrer, Sigrid .

PLOS ONE, 2013, 8 (11)

[3] Influence of ionic liquid and ionic salt on protein against the reactive species generated using dielectric barrier discharge plasma [J].

Attri, Pankaj ;

Sarinont, Thapanut ;

Kim, Minsup ;

Amano, Takaaki ;

Koga, Kazunori ;

Cho, Art E. ;

Choi, Eun Ha ;

Shiratani, Masaharu .

SCIENTIFIC REPORTS, 2015, 5

[4] RETRACTED: Utility of plasma: a new road from physics to chemistry(Retracted article. See vol.7,pg.15735,2017) [J].

Attri, Pankaj ;

Arora, Bharti ;

Choi, Eun Ha .

RSC ADVANCES, 2013, 3 (31) :12540-12567

[5] Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial [J].

Bang, Yung-Jue ;

Van Cutsem, Eric ;

Feyereislova, Andrea ;

Chung, Hyun C. ;

Shen, Lin ;

Sawaki, Akira ;

Lordick, Florian ;

Ohtsu, Atsushi ;

Omuro, Yasushi ;

Satoh, Taroh ;

Aprile, Giuseppe ;

Kulikov, Evgeny ;

Hill, Julie ;

Lehle, Michaela ;

Ruschoff, Josef ;

Kang, Yoon-Koo .

LANCET, 2010, 376 (9742) :687-697

[6] Effects of Low Temperature Plasmas on Cancer Cells [J].

Barekzi, Nazir ;

Laroussi, Mounir .

PLASMA PROCESSES AND POLYMERS, 2013, 10 (12) :1039-1050

[7] Evaluation of plasma skin regeneration technology in low-energy full-facial rejuvenation [J].

Bogle, Melissa A. ;

Arndt, Kenneth A. ;

Dover, Jeffrey S. .

ARCHIVES OF DERMATOLOGY, 2007, 143 (02) :168-174

[8]

Chen Z., 2016, ARXIV160403051

[9] Cold Plasma Accelerates the Uptake of Gold Nanoparticles Into Glioblastoma Cells [J].

Cheng, Xiaoqian ;

Rajjoub, Kenan ;

Sherman, Jonathan ;

Canady, Jerome ;

Recek, Nina ;

Yan, Dayun ;

Bian, Ka ;

Murad, Ferid ;

Keidar, Michael .

PLASMA PROCESSES AND POLYMERS, 2015, 12 (12) :1364-1369

[10] Synergistic effect of gold nanoparticles and cold plasma on glioblastoma cancer therapy [J].

Cheng, Xiaoqian ;

Murphy, William ;

Recek, Nina ;

Yan, Dayun ;

Cvelbar, Uros ;

Vesel, Alenka ;

Mozetic, Miran ;

Canady, Jerome ;

Keidar, Michael ;

Sherman, Jonathan H. .

JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2014, 47 (33)

← 1 2 3 4 5 →