Resveratrol-loaded nanoparticles conjugated with kidney injury molecule-1 as a drug delivery system for potential use in chronic kidney disease

被引：49

作者：

Lin, Yuh-Feng ^{[1
,2
]}

Lee, Yu-Hsuan ^{[3
]}

Hsu, Yung-Ho ^{[1
,4
]}

Chen, Yi-Jie ^{[1
]}

Lin, Yuan-Feng ^{[2
]}

Cheng, Fong-Yu ^{[5
]}

Chiu, Hui-Wen ^{[1
,2
]}

机构：

[1] Taipei Med Univ, Shuang Ho Hosp, Div Nephrol, Dept Internal Med, Taipei, Taiwan

[2] Taipei Med Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan

[3] Natl Cheng Kung Univ, Dept Food Safety Hyg & Risk Management, Coll Med, Tainan, Taiwan

[4] Taipei Med Univ, Sch Med, Dept Internal Med, Coll Med, Taipei, Taiwan

[5] Chinese Culture Univ, Dept Chem, Taipei, Taiwan

来源：

NANOMEDICINE | 2017年 / 12卷 / 22期

关键词：

autophagy; chronic kidney disease; inflammasome; kidney injury molecule-1; resveratrol; NLRP3 INFLAMMASOME ACTIVATION; DIABETIC-NEPHROPATHY; RENAL FIBROSIS; IN-VITRO; AUTOPHAGY; ANTIOXIDANT; PATHWAY; AGENT; CELLS; KIM-1;

D O I：

10.2217/nnm-2017-0256

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: We used resveratrol (Res)-loaded nanoparticles (Res NPs) as a novel method for improving the pharmacokinetic properties of Res and analyzed the effect of Res NPs in chronic kidney disease (CKD). Materials & methods: We coupled anti-kidney injury molecule-1 antibodies to Res NPs and analyzed safety and efficacy. Results: Res NPs had low toxicity and induced autophagy. Res NPs inhibited the NLRP3 inflammasome and IL-1 beta secretion. Higher NLRP3 expression levels were observed in peripheral blood monocytic cells of CKD patients than healthy individuals. Treatment with kidney injury molecule-1-Res NPs significantly reduced creatinine and protected against tubulointerstitial injury in a murine model of CKD. Conclusion: Res NPs through NLRP3 inflammasome attenuation and autophagy induction may be as a strategy to prevent CKD.

引用

页码：2741 / 2756

页数：16

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