Resveratrol-loaded nanoparticles conjugated with kidney injury molecule-1 as a drug delivery system for potential use in chronic kidney disease

被引：45
作者：
Lin, Yuh-Feng [1 ,2 ]
Lee, Yu-Hsuan [3 ]
Hsu, Yung-Ho [1 ,4 ]
Chen, Yi-Jie [1 ]
Lin, Yuan-Feng [2 ]
Cheng, Fong-Yu [5 ]
Chiu, Hui-Wen [1 ,2 ]
机构：
[1] Taipei Med Univ, Shuang Ho Hosp, Div Nephrol, Dept Internal Med, Taipei, Taiwan
[2] Taipei Med Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan
[3] Natl Cheng Kung Univ, Dept Food Safety Hyg & Risk Management, Coll Med, Tainan, Taiwan
[4] Taipei Med Univ, Sch Med, Dept Internal Med, Coll Med, Taipei, Taiwan
[5] Chinese Culture Univ, Dept Chem, Taipei, Taiwan
来源：
NANOMEDICINE | 2017年 / 12卷 / 22期
关键词：
autophagy; chronic kidney disease; inflammasome; kidney injury molecule-1; resveratrol; NLRP3 INFLAMMASOME ACTIVATION; DIABETIC-NEPHROPATHY; RENAL FIBROSIS; IN-VITRO; AUTOPHAGY; ANTIOXIDANT; PATHWAY; AGENT; CELLS; KIM-1;
D O I：
10.2217/nnm-2017-0256
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: We used resveratrol (Res)-loaded nanoparticles (Res NPs) as a novel method for improving the pharmacokinetic properties of Res and analyzed the effect of Res NPs in chronic kidney disease (CKD). Materials & methods: We coupled anti-kidney injury molecule-1 antibodies to Res NPs and analyzed safety and efficacy. Results: Res NPs had low toxicity and induced autophagy. Res NPs inhibited the NLRP3 inflammasome and IL-1 beta secretion. Higher NLRP3 expression levels were observed in peripheral blood monocytic cells of CKD patients than healthy individuals. Treatment with kidney injury molecule-1-Res NPs significantly reduced creatinine and protected against tubulointerstitial injury in a murine model of CKD. Conclusion: Res NPs through NLRP3 inflammasome attenuation and autophagy induction may be as a strategy to prevent CKD.
引用
收藏
页码：2741 / 2756
页数：16
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