Nickel-Catalyzed Cross-Coupling of Aryl Fluorides and Organozinc Reagents

被引：65

作者：

Zhu, Feng

Wang, Zhong-Xia ^{[1
]}

机构：

[1] Univ Sci & Technol China, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 10期

基金：

中国国家自然科学基金;

关键词：

C-F ACTIVATION; GRIGNARD-REAGENTS; BOND FORMATION; ALKYL FLUORIDES; HALIDES; CHLORIDES; SUBSTITUTION; EXPLORATION; COMPLEXES; MECHANISM;

D O I：

10.1021/jo500619f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ni(PCy3)(2)Cl-2 was demonstrated to effectively catalyze cross-coupling of aryl fluorides and organozinc reagents. Both electron-poor and -rich aryl fluorides Can react effectively with nucleophiles including aryl-, methyl-, and benzylzinc chlorides. A wide range of substituents and functional groups are tolerated. In the presence of a directing group, PhC(O), the reaction is selective for cleavage of the C-F bond ortho to the carbonyl substituent in a difluoroarene.

引用

页码：4285 / 4292

页数：8

共 79 条

[1] Efficient aryl-(hetero)aryl coupling by activation of C-Cl and C-F bonds using nickel complexes of air-stable phosphine oxides [J].