Cutting edge:: DNA polymerases μ and λ are dispensable for Ig gene hypermutation

被引：113

作者：

Bertocci, B

De Smet, A

Flatter, E

Dahan, A

Bories, JC

Landreau, C

Weill, JC

Reynaud, CA

机构：

[1] CHU Necker Enfants Malad, Fac Med, Unite 373, Inst Natl St & Rech Med, F-75730 Paris 15, France

[2] Hop St Louis, Unite 462, Inst Natl St & Rech Med, Paris, France

[3] Ctr Natl Rech Sci, Serv Expt Anim & Transgenese, Villejuif, France

来源：

JOURNAL OF IMMUNOLOGY | 2002年 / 168卷 / 08期

关键词：

D O I：

10.4049/jimmunol.168.8.3702

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mutations arising in Ig V genes during an immune response are most likely introduced by one or several error-prone DNA polymerases. Many of the recently described nonreplicative DNA polymerases have an intrinsic fidelity compatible with such an activity, the strongest candidates being polymerase (pol) eta, pol iota, pol zeta, and pol mu. We report in this work that mice inactivated for either of the two polymerases related to pol beta (i.e., pol mu and pol lambda) are viable and fertile and display a normal hypermutation pattern.

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页码：3702 / 3706

页数：5

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