BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs

被引：8520

作者：

Simao, Felipe A.

Waterhouse, Robert M.

Ioannidis, Panagiotis

Kriventseva, Evgenia V.

Zdobnov, Evgeny M. ^{[1
]}

机构：

[1] Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland

来源：

BIOINFORMATICS | 2015年 / 31卷 / 19期

基金：

瑞士国家科学基金会;

关键词：

QUALITY; TOOL;

D O I：

10.1093/bioinformatics/btv351

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: Genomics has revolutionized biological research, but quality assessment of the resulting assembled sequences is complicated and remains mostly limited to technical measures like N50. Results: We propose a measure for quantitative assessment of genome assembly and annotation completeness based on evolutionarily informed expectations of gene content. We implemented the assessment procedure in open-source software, with sets of Benchmarking Universal Single-Copy Orthologs, named BUSCO.

引用

收藏

页码：3210 / 3212

页数：3

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