Bioactive phenolics from Seriphidium stenocephalum

被引：9

作者：

Shafiq, Nusrat ^{[1
]}

Riaz, Naheed ^{[1
]}

Ahmed, Shabir ^{[1
,2
]}

Ashraf, Muhammad ^{[3
]}

Ejaz, Syeda Abida ^{[4
]}

Ahmed, Ishtiaq ^{[5
]}

Saleem, Muhammad ^{[1
]}

Touseef, Muhammad Imran ^{[1
]}

Tareen, Rasool Bakhsh ^{[6
]}

Jabbar, Abdul ^{[1
]}

机构：

[1] Islamia Univ Bahawalpur, Dept Chem, Bahawalpur 63100, Pakistan

[2] Govt Postgrad Coll, Dept Chem, Bahawalpur 63100, Pakistan

[3] Islamia Univ Bahawalpur, Dept Biochem & Biotechnol, Bahawalpur 63100, Pakistan

[4] Islamia Univ Bahawalpur, Dept Pharm, Bahawalpur 63100, Pakistan

[5] KIT, DFG Ctr Funct Nanostruct, D-76131 Karlsruhe, Germany

[6] Univ Baluchistan, Dept Bot, Quetta, Pakistan

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2013年 / 15卷 / 03期

关键词：

Seriphidium stenocephalum; methanolic extract; secondary metabolites; characterization; phenolics; enzyme inhibition; CHEMICAL-CONSTITUENTS; FLAVONOIDS; GLYCOSIDES; ARTEMISIA; LEAVES; C-13;

D O I：

10.1080/10286020.2013.763226

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chromatographic separation of the ethyl acetate soluble part of the methanolic extract from Seriphidium stenocephalum yielded three new compounds: stenocepflavone (1), stenocepflavan (2), and stenocephol (3), together with cirsimaritin (4), 5,7,5-trihydroxy-3,4,6-trimethoxyflavone (5), 5,6,7,5-tetrahydroxy-4-methoxyflavone (6), and axillaroside (7). All isolates were characterized with the help of spectroscopic data including 1D, 2D NMR, and high resolution mass spectrometry and/or in comparison with the related compounds in literature. All compounds were tested for in vitro enzyme inhibitory activities against acetylcholinesterase, butyrylcholinesterase, and lipoxygenase. Compounds 1 and 47 exhibited significant activity against all the tested enzymes, whereas compounds 2 and 3 were found inactive.

引用

页码：286 / 293

页数：8

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