Virus-mimicking nano-constructs as a contrast agent for near infrared photoacoustic imaging

被引：36

作者：

Gupta, Sharad ^{[1
]}

Chatni, Muhammad R. ^{[2
]}

Rao, Ayala L. N. ^{[3
]}

Vullev, Valentine I. ^{[1
]}

Wang, Lihong V. ^{[2
]}

Anvari, Bahman ^{[1
]}

机构：

[1] Univ Calif Riverside, Dept Bioengn, Riverside, CA 92521 USA

[2] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA

[3] Univ Calif Riverside, Dept Plant Pathol & Microbiol, Riverside, CA 92521 USA

来源：

NANOSCALE | 2013年 / 5卷 / 05期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

COWPEA MOSAIC-VIRUS; INDOCYANINE GREEN; VIRAL NANOPARTICLES; IN-VIVO; STABILITY; PARTICLES; TOXICITY; DELIVERY; PLATFORM; THERAPY;

D O I：

10.1039/c3nr34124k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the first proof-of-principle demonstration of photoacoustic imaging using a contrast agent composed of a plant virus protein shell, which encapsulates indocyanine green (ICG), the only FDA-approved near infrared chromophore. These nano-constructs can provide higher photoacoustic signals than blood in tissue phantoms, and display superior photostability compared to non-encapsulated ICG. Our preliminary results suggest that the constructs do not elicit an acute immunogenic response in healthy mice.

引用

页码：1772 / 1776

页数：5

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