β-cell death during progression to diabetes

被引：726
作者：
Mathis, D
Vence, L
Benoist, C
机构：
[1] Brigham & Womens Hosp, Joslin Diabet Ctr, Dept Med, Sect Immunol & Innumogenet, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA 02215 USA
来源：
NATURE | 2001年 / 414卷 / 6865期
关键词：
D O I：
10.1038/414792a
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The hallmark of type 1 diabetes is specific destruction of pancreatic islet beta -cells. Apoptosis of beta -cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. beta -Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes.
引用
收藏
页码：792 / 798
页数：7
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