Zataria multiflora affects clinical symptoms, oxidative stress and cytokines in asthmatic patient: A randomized, double blind, placebo-controlled, phase II clinical trial

被引：18

作者：

Alavinezhad, Azam ^{[1
,2
]}

Ghorani, Vahideh ^{[1
,2
]}

Rajabi, Omid ^{[3
]}

Boskabady, Mohammad Hossein ^{[1
,2
]}

机构：

[1] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran

[2] Mashhad Univ Med Sci, Sch Med, Dept Physiol, Mashhad 9177948564, Razavi Khorasan, Iran

[3] Mashhad Univ Med Sci, Sch Pharm, Dept Drug & Food Control, Mashhad, Razavi Khorasan, Iran

来源：

CYTOKINE | 2020年 / 133卷

关键词：

Asthma; Zataria multiflora; Cytokines; Oxidative stress; Clinical symptoms; Pulmonary function tests; PULMONARY-FUNCTION TESTS; TRACHEAL RESPONSIVENESS; DIFFERENTIAL WBC; ESSENTIAL OIL; NITRIC-OXIDE; IN-VITRO; LUNG PATHOLOGY; CARVACROL; EXTRACT; ANTIOXIDANT;

D O I：

10.1016/j.cyto.2020.155169

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Z. multiflora effect on clinical symptoms, pulmonary function tests (PFT), oxidative stress and cytokine levels in asthmatic patients were evaluated. Methods: 36 asthmatic patients were divided to; placebo group (P), two groups treated with Z. multiflora extract (5 and 10 mg/kg/day, as Z5 and Z10, respectively), (n = 12 in each group). Medications were administered three times a day for two months and several parameters were evaluated before treatment (step 0), one (step 1) and two months (step 2) after treatment. Results: Clinical symptoms and PFTs were significantly improved in Z5 and Z10 groups in steps 1 and 2 compared to step 0 (p < 0.05 to p < 0.001). Improvement of oxidative stress, cytokines levels and their gene expression after treatment with both doses of extract were observed in step 2 compared to step 0 (p < 0.05 to p < 0.001). Conclusion: These results indicated therapeutic value of Z. multiflora for the management of asthma.

引用

页数：12