Apelin and its receptor APJ in cardiovascular diseases

被引：105

作者：

Yu, Xiao-Hua ^{[1
]}

Tang, Zhi-Bin ^{[3
]}

Liu, Li-Jing ^{[4
]}

Qian, Hong ^{[4
]}

Tang, Shi-Lin ^{[3
]}

Zhang, Da-Wei ^{[5
,6
]}

Tian, Guo-Ping ^{[7
]}

Tang, Chao-Ke ^{[1
,2
]}

机构：

[1] Univ South China, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China

[2] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China

[3] Univ South China, Affiliated Hosp 1, Dept Orthoped, Hengyang 421001, Hunan, Peoples R China

[4] Huaihua Med Coll, Dept Clin Med, Huaihua 418000, Hunan, Peoples R China

[5] Univ Alberta, Dept Pediat, Edmonton, AB T6G 2S2, Canada

[6] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB T6G 2S2, Canada

[7] Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Hunan, Peoples R China

来源：

CLINICA CHIMICA ACTA | 2014年 / 428卷

关键词：

Apelin; APJ; Atherosclerosis; CAD; Heart failure; Hypertension; ELEVATION MYOCARDIAL-INFARCTION; PERSISTENT ATRIAL-FIBRILLATION; EARLY CAROTID ATHEROSCLEROSIS; CHRONIC HEART-FAILURE; ENDOTHELIAL-CELLS; BLOOD-PRESSURE; REPERFUSION INJURY; PEPTIDE APELIN; IN-VIVO; CARDIAC CONTRACTILITY;

D O I：

10.1016/j.cca.2013.09.001

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Apelin is an adipokine that has been identified as an endogenous ligand for the orphan receptor APJ. Apelin and APJ are expressed in a diverse range of tissues with particular preponderance for the heart and vasculature. Apelin has powerful positive inotropic actions and causes endothelium- and nitric oxide-dependent vasodilatation. Growing evidence shows that apelin/APJ system functions as a critical mediator of cardiovascular homeostasis and is involved in the pathophysiology of cardiovascular diseases. Targeting apelin/APJ axis produces protection against cardiovascular diseases. In the current review we have summarized recent data concerning the role and therapeutic potential of apelin/APJ in several major cardiovascular diseases. An increased understanding of the cardiovascular actions of apelin/APJ system will help to develop novel therapeutic interventions for cardiovascular diseases. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：1 / 8

页数：8

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