Folic acid supplementation and dietary folate intake, and risk of preeclampsia

被引：52

作者：

Wang, Y. ^{[1
]}

Zhao, N. ^{[2
]}

Qiu, J. ^{[1
]}

He, X. ^{[1
]}

Zhou, M. ^{[1
]}

Cui, H. ^{[1
]}

Lv, L. ^{[1
]}

Lin, X. ^{[1
]}

Zhang, C. ^{[1
]}

Zhang, H. ^{[1
]}

Xu, R. ^{[1
]}

Zhu, D. ^{[1
]}

Dang, Y. ^{[1
]}

Han, X. ^{[1
]}

Zhang, H. ^{[1
]}

Bai, H. ^{[1
]}

Chen, Y. ^{[1
]}

Tang, Z. ^{[1
]}

Lin, R. ^{[1
]}

Yao, T. ^{[1
]}

Su, J. ^{[1
]}

Xu, X. ^{[1
]}

Liu, X. ^{[1
]}

Wang, W. ^{[1
]}

Ma, B. ^{[1
]}

Liu, S. ^{[1
]}

Qiu, W. ^{[1
]}

Huang, H. ^{[2
]}

Liang, J. ^{[2
]}

Wang, S. ^{[3
]}

Ehrenkranz, R. A. ^{[4
]}

Kim, C. ^{[5
]}

Liu, Q. ^{[1
]}

Zhang, Y. ^{[2
]}

机构：

[1] Gansu Prov Matern & Child Care Hosp, Lanzhou 730050, Gansu, Peoples R China

[2] Yale Univ, Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT 06520 USA

[3] Shanxi Med Univ, Sch Publ Hlth, Dept Epidemiol, Taiyuan, Shanxi, Peoples R China

[4] Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06520 USA

[5] NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Sci, Bethesda, MD 20892 USA

来源：

EUROPEAN JOURNAL OF CLINICAL NUTRITION | 2015年 / 69卷 / 10期

基金：

美国国家卫生研究院;

关键词：

PERICONCEPTIONAL MULTIVITAMIN USE; PLASMA HOMOCYSTEINE LEVELS; HOMOCYST(E)INE CONCENTRATIONS; GESTATIONAL HYPERTENSION; PREGNANCY OUTCOMES; WOMEN; FORTIFICATION; MORTALITY; ECLAMPSIA; DISEASE;

D O I：

10.1038/ejcn.2014.295

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

BACKGROUND/OBJECTIVES: Folic acid supplementation has been suggested to reduce the risk of preeclampsia. However, results from few epidemiologic studies have been inconclusive. We investigated the hypothesis that folic acid supplementation and dietary folate intake before conception and during pregnancy reduce the risk of preeclampsia. SUBJECTS/ METHODS: A birth cohort study was conducted in 2010-2012 at the Gansu Provincial Maternity & Child Care Hospital in Lanzhou, China. A total of 10 041 pregnant women without chronic hypertension or gestational hypertension were enrolled. RESULTS: Compared with nonusers, folic acid supplement users had a reduced risk of preeclampsia (OR = 0.61, 95% CI: 0.43-0.87). A significant dose-response of duration of use was observed among women who used folic acid supplemention during pregnancy only (P-trend = 0.007). The reduced risk associated with folic acid supplement was similar for mild or severe preeclampsia and for early-or late-onset preeclampsia, although the statistical significant associations were only observed for mild (OR = 0.50, 95% CI: 0.30-0.81) and late-onset (OR = 0.60, 95% CI: 0.42-0.86) preeclampsia. The reduced risk associated with dietary folate intake during pregnancy was only seen for severe preeclampsia (OR = 0.52, 95% CI: 0.31-0.87, for the highest quartile of dietary folate intake compared with the lowest). CONCLUSIONS: Our study results suggest that folic acid supplementation and higher dietary folate intake during pregnancy reduce the risk of preeclampsia. Future studies are needed to confirm the associations.

引用

页码：1145 / 1150

页数：6

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