A Facile Eco-Friendly One-Pot Five-Component Synthesis of Novel 1,2,3-Triazole-Linked Pentasubstituted 1,4-Dihydropyridines and their Biological and Photophysical Studies

被引：29
作者：
Singh, Harjinder [1 ]
Sindhu, Jayant [1 ]
Khurana, Jitender M. [1 ]
Sharma, Chetan [2 ]
Aneja, Kamal R. [2 ]
机构：
[1] Univ Delhi, Dept Chem, Delhi 110007, India
[2] Kurukshetra Univ, Dept Microbiol, Kurukshetra 136119, Haryana, India
来源：
AUSTRALIAN JOURNAL OF CHEMISTRY | 2013年 / 66卷 / 09期
关键词：
MULTICOMPONENT REACTIONS; CALCIUM-ANTAGONISM; ANTIBACTERIAL; DERIVATIVES; CHEMISTRY; OIL;
D O I：
10.1071/CH13217
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An eco-friendly one-pot five-component synthesis of novel 1,2,3-triazole-linked pentasubstituted 1,4-dihydropyridines under ultrasonic and microwave irradiation in polyethylene glycol (PEG) 400 is described. All newly synthesised compounds were evaluated for antibacterial activity, antifungal activity, antioxidant activity, and photophysical properties. Antimicrobial activity was evaluated against six microbial strains. All compounds exhibited antifungal activity against Aspergillus niger and Aspergillus flavus and moderate antibacterial activity against Gram positive bacteria (Staphylococcus aureus and Bacillus subtilis). Antioxidant activity was evaluated using a 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay. All compounds showed good to moderate antioxidant activity. Furthermore all new compounds showed strong fluorescence in solution.
引用
收藏
页码：1088 / 1096
页数：9
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