Asymptomatic spinal cord lesions do not predict the time to disability in patients with early multiple sclerosis

被引：17
作者：
Dekker, Iris [1 ,2 ]
Sombekke, Madeleine H. [1 ]
Witte, Birgit I. [3 ]
Geurts, Jeroen J. G. [4 ]
Barkhof, Frederik [2 ,5 ,6 ]
Uitdehaag, Bernard M. J. [1 ]
Killestein, Joep [1 ]
Wattjes, Mike P. [2 ]
机构：
[1] Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Neurosci Amsterdam,MS Ctr Amsterdam, De Boelelaan 1118, NL-1081 HZ Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, Dept Radiol & Nucl Med, Med Ctr, Neurosci Amsterdam,MS Ctr Amsterdam, Amsterdam, Netherlands
[3] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands
[4] Vrije Univ Amsterdam, Med Ctr, Dept Anat & Neurosci, Neurosci Amsterdam,MS Ctr Amsterdam, Amsterdam, Netherlands
[5] UCL, Inst Neurol, London, England
[6] UCL, Inst Healthcare Engn, London, England
来源：
MULTIPLE SCLEROSIS JOURNAL | 2018年 / 24卷 / 04期
关键词：
Clinically isolated syndrome; multiple sclerosis; disability; magnetic resonance imaging; asymptomatic spinal cord lesions; progression; CLINICALLY ISOLATED SYNDROMES; MAGNIMS CONSENSUS GUIDELINES; MRI; PROGNOSIS; BRAIN; DIAGNOSIS; CRITERIA;
D O I：
10.1177/1352458517736147
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: The presence of asymptomatic spinal cord (SC) lesions in patients with clinically isolated syndrome (CIS) or relapsing-remitting multiple sclerosis (RRMS) predicts conversion to clinically definite multiple sclerosis (CDMS). The relation between asymptomatic SC abnormalities and disability progression warrants further investigation. Objective: To determine the prognostic value of asymptomatic SC lesions in CIS and early RRMS with respect to the time to disability development. Methods: Clinical and demographic data, brain and SC magnetic resonance imaging (MRI) were collected of CIS or early RRMS patients. Two main analyses were performed. For the first analysis, patients were divided into two groups: (1) patients with asymptomatic SC lesions and (2) patients without SC lesions and patients with symptomatic SC lesions. The second analysis excluded patients with symptomatic SC lesions. Incidence curves were used to analyse differences between these groups in time to the development of disability and time to a second relapse. Results: A total of 178 patients were included, and 42 patients (23.6%) had asymptomatic SC lesions. No significant differences were found on the time to disability development or the time to a second event. Conclusion: Asymptomatic SC lesions early in the disease course do not predict the time to disability development in patients diagnosed with CIS or early RRMS.
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收藏
页码：481 / 490
页数：10
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