Aniquinazolines A-D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans

被引：46

作者：

An, Chun-Yan ^{[1
,2
]}

Li, Xiao-Ming ^{[1
]}

Li, Chun-Shun ^{[1
]}

Wang, Ming-Hui ^{[1
,2
]}

Xu, Gang-Ming ^{[1
]}

Wang, Bin-Gui ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

MARINE DRUGS | 2013年 / 11卷 / 07期

基金：

中国国家自然科学基金;

关键词：

mangrove; endophytic fungus; Aspergillus nidulans; secondary metabolites; bioactivity; METABOLITES; ANTIFUNGAL; FUMIGATUS;

D O I：

10.3390/md11072682

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new quinazolinone alkaloids, namely, aniquinazolines A-D (1-4), were isolated and identified from the culture of Aspergillus nidulans MA-143, an endophytic fungus obtained from the leaves of marine mangrove plant Rhizophora stylosa. The structures of the new compounds were elucidated by spectroscopic analysis, and their absolute configurations were determined on the basis of chiral HPLC analysis of the acidic hydrolysates. The structure for 1 was confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for antibacterial and cytotoxic activity as well as brine shrimp (Artemia salina) lethality.

引用

页码：2682 / 2694

页数：13

共 22 条

[1] Chemical composition, antibacterial and antifungal activities of the essential oil of Haplophyllum tuberculatum from Oman [J].

Al-Burtamani, SKS ;

Fatope, MO ;

Marwah, RG ;

Onifade, AK ;

Al-Saidi, SH .

JOURNAL OF ETHNOPHARMACOLOGY, 2005, 96 (1-2) :107-112

[2] Complexity Generation in Fungal Peptidyl Alkaloid Biosynthesis: Oxidation of Fumiquinazoline A to the Heptacyclic Hemiaminal Fumiquinazoline C by the Flavoenzyme Af12070 from Aspergillus fumigatus [J].

Ames, Brian D. ;

Haynes, Stuart W. ;

Gao, Xue ;

Evans, Bradley S. ;

Kelleher, Neil L. ;

Tang, Yi ;

Walsh, Christopher T. .

BIOCHEMISTRY, 2011, 50 (40) :8756-8769

[3]

[Anonymous], 1996, SADABS SOFTWARE EMPI

[4] SPIROQUINAZOLINE, A NOVEL SUBSTANCE-P INHIBITOR WITH A NEW CARBON SKELETON, ISOLATED FROM ASPERGILLUS FLAVIPES [J].

BARROW, CJ ;

SUN, HH .

JOURNAL OF NATURAL PRODUCTS, 1994, 57 (04) :471-476

[5] ANTINEOPLASTIC AND ANTIHERPETIC ACTIVITY OF SPERMIDINE CATECHOLAMIDE IRON CHELATORS [J].

BERGERON, RJ ;

CAVANAUGH, PF ;

KLINE, SJ ;

HUGHES, RG ;

ELLIOTT, GT ;

PORTER, CW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 121 (03) :848-854

[6] Cristatumins A-D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220 [J].

Du, Feng-Yu ;

Li, Xiao-Ming ;

Li, Chun-Shun ;

Shang, Zhuo ;

Wang, Bin-Gui .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (14) :4650-4653

[7] Cottoquinazoline A and Cotteslosins A and B, Metabolites from an Australian Marine-Derived Strain of Aspergillus versicolor [J].

Fremlin, Leith J. ;

Piggott, Andrew M. ;

Lacey, Ernest ;

Capon, Robert. J. .

JOURNAL OF NATURAL PRODUCTS, 2009, 72 (04) :666-670

[8] Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S [J].

Gao, Shu-Shan ;

Li, Xiao-Ming ;

Du, Feng-Yu ;

Li, Chun-Shun ;

Proksch, Peter ;

Wang, Bin-Gui .

MARINE DRUGS, 2011, 9 (01) :59-70

[9] STRUCTURE OF CURACIN-A, A NOVEL ANTIMITOTIC, ANTIPROLIFERATIVE, AND BRINE SHRIMP TOXIC NATURAL PRODUCT FROM THE MARINE CYANOBACTERIUM LYNGBYA-MAJUSCULA [J].

GERWICK, WH ;

PROTEAU, PJ ;

NAGLE, DG ;

HAMEL, E ;

BLOKHIN, A ;

SLATE, DL .

JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (06) :1243-1245

[10] Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp IFB-E015 [J].

Jiao, Rui H. ;

Xu, Shu ;

Liu, Jun Y. ;

Ge, Hui M. ;

Ding, Hui ;

Xu, Chen ;

Zhu, Hai L. ;

Tan, Ren X. .

ORGANIC LETTERS, 2006, 8 (25) :5709-5712

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