Islet transplantation as a clinical tool: present state and future perspectives

被引：5
作者：
Eliaschewitz, Freddy Goldberg [1 ,2 ,3 ,4 ]
Franco, Denise Reis [1 ,2 ,4 ]
Mares-Guia, Thiago Renno [1 ]
Noronha, Irene L. [1 ,5 ]
Labriola, Leticia [1 ]
Sogayar, Mari Cleide [1 ,6 ]
机构：
[1] Univ Sao Paulo, Nucleo Terapia Celular & Mol NUCEL, BR-09500900 Sao Paulo, Brazil
[2] Ctr Pesquisa Clin, Sao Paulo, Brazil
[3] Hosp Heliopolis, Sao Paulo, Brazil
[4] Notre Dome Intermed Sistema Saude, Ctr Pesquisa Med, Sao Paulo, Brazil
[5] Univ Sao Paulo, Fac Med, Dept Clin Med, BR-09500900 Sao Paulo, Brazil
[6] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-09500900 Sao Paulo, Brazil
来源：
ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA | 2009年 / 53卷 / 01期
关键词：
Brittle diabetes; islet transplantation; cell therapy; type; 1; diabetes; immunosupression; BETA-CELL FUNCTION; MEDIATED INFLAMMATORY REACTION; PANCREATIC-ISLETS; TISSUE FACTOR; CULTURED ISLETS; SINGLE-DONOR; IN-VITRO; TYPE-1; TERM; MONOTHERAPY;
D O I：
10.1590/S0004-27302009000100004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Islet transplant is an innovative treatment for type 1 diabetic patients, which still lies between experimental and approved transplant therapy. Islet cells are seeded in a non-physiological territory where an uncertain fraction will be able to adapt and survive. Thus, the challenge lies in improving the whole procedure, employing the tools of cell biology, immunology and laboratory techniques, in order to reach the results obtained with whole organ transplant. This review describes the procedure, its progress to the present methodology and clinical results obtained. Future perspectives of islet transplantation in the light of recent biotechnological advances are also focused. Arq Bras Endocrinol Metab. 2009;53(1):15-23.
引用
收藏
页码：15 / 23
页数：9
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