Diagnosis of rickettsial diseases in dogs and cats

被引:46
作者
Allison, Robin W. [1 ]
Little, Susan E. [1 ]
机构
[1] Oklahoma State Univ, Dept Vet Pathobiol, Ctr Vet Hlth Sci, Stillwater, OK 74078 USA
关键词
Anaplasmosis; ehrlichiosis; morula; rickettsiosis; serology; tick-borne; REAL-TIME PCR; HUMAN GRANULOCYTIC EHRLICHIOSIS; CANINE MONOCYTIC EHRLICHIOSIS; FLUORESCENT-ANTIBODY TEST; POLYMERASE-CHAIN-REACTION; MOUNTAIN-SPOTTED-FEVER; INDIRECT IMMUNOFLUORESCENCE ASSAY; SALMON POISONING DISEASE; RISTICII GENOMIC DNA; ANAPLASMA-PHAGOCYTOPHILUM;
D O I
10.1111/vcp.12040
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Rickettsial agents, including those in the genera Anaplasma, Ehrlichia, Neorickettsia, and Rickettsia, are important and common vector-borne pathogens of dogs and cats. Disease induced by these organisms ranges from clinically inapparent to severe and potentially fatal. However, laboratory confirmation of a rickettsial etiology can be complicated by a number of factors, including the wide spectrum of disease induced by these organisms, an often low and widely fluctuating level of organism present in infected animals, cross-reactions on serologic and molecular assays, and the presence of co-infections. Correct diagnosis is most likely to be reached when multiple diagnostic strategies, including careful microscopic examination of stained blood films or tissues, both specific and broad serologic tests, and a suite of molecular detection assays, are used in concert. Accurate interpretation of diagnostic tests requires awareness of the likelihood for multiple agents, including novel organisms, to be responsible for the results seen in a given patient. This review provides an overview of current strategies used to diagnose rickettsial infections in dogs and cats.
引用
收藏
页码:127 / 144
页数:18
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