Microbial genetics - Hypermutation under stress

被引：45

作者：

Bridges, BA

机构：

[1] MRC Cell Mutation Unit,

[2] University of Sussex,undefined

来源：

NATURE | 1997年 / 387卷 / 6633期

关键词：

D O I：

10.1038/42370

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When microorganisms are starved of nutrients, the rate of mutation of their genomes accelerates. But are these mutations directed towards those genes that might prove effective in rectifying the nutritional deficiency concerned, or are they random? New studies on a commonly used system (mutants of Escherichia coli that cannot use lactose) point to the second possibility.

引用

收藏

页码：557 / 558

页数：2

相关论文

共 11 条

[1] Effect of mutY and mutM/fpg-1 mutations on starvation-associated mutation in Escherichia coli: Implications for the role of 7,8-dihydro-8-oxoguanine [J].

Bridges, BA ;

Sekiguchi, M ;

Tajiri, T .

MOLECULAR & GENERAL GENETICS, 1996, 251 (03) :352-357

[2] MUTY DIRECTS MUTATION [J].

BRIDGES, BA .

NATURE, 1995, 375 (6534) :741-741

[3] THE ORIGIN OF MUTANTS [J].

CAIRNS, J ;

OVERBAUGH, J ;

MILLER, S .

NATURE, 1988, 335 (6186) :142-145

[4]

CAIRNS J, 1991, GENETICS, V128, P695

[5] Nonadaptive mutations occur on the F' episome during adaptive mutation conditions in Escherichia coli [J].

Foster, PL .

JOURNAL OF BACTERIOLOGY, 1997, 179 (05) :1550-1554

[6]

FOSTER PL, 1993, ANNU REV MICROBIOL, V47, P467

[7]

FOSTER PL, 1994, GENETICS, V138, P253

[8] ADAPTIVE EVOLUTION OF HIGHLY MUTABLE LOCI IN PATHOGENIC BACTERIA [J].

MOXON, ER ;

RAINEY, PB ;

NOWAK, MA ;

LENSKI, RE .

CURRENT BIOLOGY, 1994, 4 (01) :24-33

[9] Recombination-dependent mutation in non-dividing cells [J].

Rosenberg, SM ;

Harris, RS ;

Longerich, S ;

Galloway, AM .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 1996, 350 (01) :69-76

[10] Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutation [J].

Torkelson, J ;

Harris, RS ;

Lombardo, MJ ;

Nagendran, J ;

Thulin, C ;

Rosenberg, SM .

EMBO JOURNAL, 1997, 16 (11) :3303-3311